Evidence map›Paper›PMID 33504070›Full record

ReviewCells2021

Intracellular Sources of ROS/H

Tasuku Konno, Eduardo Pinho Melo, Joseph E Chambers, Edward Avezov

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
9.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 122 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Neuroprotective properties ofIBRO neuroscience reports · 2026
    Article
  7. Review
  8. Dynamic regulation of receptor-modulated endothelial NADPH oxidases.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Oxphos targeting ofFrontiers in oncology · 2025
    Article
  19. Article
  20. Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Tasuku KonnoDepartment of Clinical Neurosciences and UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK.
Eduardo Pinho MeloCCMAR-Centro de Ciências do Mar, Campus de Gambelas, Universidade do Algarve, 8005-139 Faro, Portugal.ORCID 0000-0002-0974-8977
Joseph E ChambersCambridge Institute for Medical Research, University of Cambridge, Cambridge CB2 0XY, UK.
Edward AvezovDepartment of Clinical Neurosciences and UK Dementia Research Institute, University of Cambridge, Cambridge CB2 0AH, UK.
University of Cambridge · GBUniversity of Algarve · PT

Funding

Medical Research Council G1002610Medical Research Council MR/R009120/1Medical Research Council MR/V028669/1
6 · The paper itself

Abstract

Reactive oxygen species (ROS) are produced continuously throughout the cell as products of various redox reactions. Yet these products function as important signal messengers, acting through oxidation of specific target factors. Whilst excess ROS production has the potential to induce oxidative stress, physiological roles of ROS are supported by a spatiotemporal equilibrium between ROS producers and scavengers such as antioxidative enzymes. In the endoplasmic reticulum (ER), hydrogen peroxide (H

Indexed as

AnimalsEndoplasmic ReticulumHumansHydrogen PeroxideIntracellular SpaceNerve DegenerationOxidative StressUnfolded Protein ResponseHydrogen Peroxideantioxidantsdementiaendoplasmic reticulumhydrogen peroxideneurodegenerationreactive oxygen speciesredox signalling

Identifiers

PMID33504070
PMCPMC7912550
OpenAlexW3125606395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.