Evidence map›Paper›PMID 33503922›Full record

ArticlePlants (Basel, Switzerland)2021

Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of

Sijia Sun, Min Jo Kim, Dya Fita Dibwe, Ashraf M Omar, Sirivan Athikomkulchai, Ampai Phrutivorapongkul, Takuya Okada, Kiyoshi Tsuge, Naoki Toyooka, Suresh Awale

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Unraveling the therapeutic potential ofIn silico pharmacology · 2024
    Article
  3. Review
  4. Review
  5. Chemical Constituents ofPlants (Basel, Switzerland) · 2022
    Article
  6. Black Ginger (Nutrients · 2022
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Sijia SunNatural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0002-3373-2828
Min Jo KimNatural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0003-2049-9411
Dya Fita DibweNatural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Ashraf M OmarNatural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Sirivan AthikomkulchaiFaculty of Pharmacy, Srinakharinwirot University, Nakhon Nayok 26120, Thailand.
Ampai PhrutivorapongkulFaculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.
Takuya OkadaFaculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
Kiyoshi TsugeFaculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.
Naoki ToyookaFaculty of Engineering, University of Toyama, 3190 Gofuku, Toyama 930-8555, Japan.ORCID 0000-0002-9568-1528
Suresh AwaleNatural Drug Discovery Laboratory, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.ORCID 0000-0002-5299-193X
University of Toyama · JPChiang Mai University · THSrinakharinwirot University · TH

Funding

Japan Society for the Promotion of Science 16K08319Kobayashi International Scholarship Foundation 2020
6 · The paper itself

Abstract

Human pancreatic tumor cells have an intrinsic ability to tolerate nutrition starvation and survive in the hypovascular tumor microenvironment, the phenomenon termed as "austerity". Searching for an agent that inhibits such tolerance to nutrient starvation and kills the pancreatic cancer cells preferentially in nutrient-starvation is a unique anti-austerity strategy in anti-cancer drug discovery. In this strategy, plant extracts and compounds are tested against PANC-1 human pancreatic cancer cell line under the conditions of nutrient-deprived medium (NDM) and nutrient-rich medium (DMEM), to discover the compounds that show selective cytotoxicity in NDM. Screening of twenty-five Thai indigenous medicinal plant extracts for their anti-austerity activity against the PANC-1 human pancreatic cancer cell line in nutrient deprived medium (NDM) resulted in the identification of four active plants,

Indexed as

anti-austerityKaempferia parviflorapancreatic cancerpreferential cytotoxicity

Identifiers

PMID33503922
PMCPMC7911922
OpenAlexW3121877977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.