ArticleNature2021
De novo design of modular and tunable protein biosensors.
Abstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
128citing papers in PubMed, 3 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
128 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Computer-Aided Lipase Engineering for Improving Their Stability and Activity in the Food Industry: State of the Art.Molecules (Basel, Switzerland) · 2023Pooled it
- Recent Advances in Biosensors for Detection of COVID-19 and Other Viruses.IEEE reviews in biomedical engineering · 2023Pooled it
- An Experimental Framework for Developing Point-of-Need Biosensors: Connecting Bio-Layer Interferometry and Electrochemical Impedance Spectroscopy.Biosensors · 2022Pooled it
- Crowdsourcing functional cell therapy binders from generative artificial intelligence.Molecular systems biology · 2026Article
- Construction of αJournal of separation science · 2026Article
- Opportunities for artificial intelligence and synthetic biology in designing living drug delivery systems.Advanced drug delivery reviews · 2026Review
- Modular Input-Output Biosensor Design UsingACS sensors · 2026Article
- High-throughput Optical Analysis to Inform Design of Electrochemical Biosensors.ACS measurement science au · 2026Review
- Tools For Building Artificial Biological Nanostructures.ACS nano · 2026Review
- Photothermal Recycling Biosensing for Continuous, Sensitive Molecular Quantification.bioRxiv : the preprint server for biology · 2026Article
- Review
- Computational design of synthetic receptors with programmable signalling activity for enhanced cancer T cell therapy.Nature biomedical engineering · 2026Article
- Impact of solvent forces and broken symmetry on the assembly of designed proteins at a liquid-solid interface.Nature communications · 2026Article
- CF2H: a cell-free two-hybrid platform for rapid protein binder screening.Nature communications · 2026Article
- Genetically encoded biosensors enabled high-throughput screening of microbial cell factories.Engineering microbiology · 2026Review
- De novo protein design: a transformative frontier in clinical protein applications.Journal of translational medicine · 2026Review
- Assessing structural prediction accuracy for nanobody-small molecule complexes.Protein engineering, design & selection : PEDS · 2026Article
- Protein engineering: status report.Protein engineering, design & selection : PEDS · 2026Review
- Computational design of 3C-like protease substrate peptide for modular detection of protease activity of coronavirus.Engineering in life sciences · 2026Article
- Biosensors for Cancer and Inflammation: Whole-Cell Biosensors for Soluble Molecules.Methods in molecular biology (Clifton, N.J.) · 2026Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
15 authors.
Alfredo Quijano-Rubio *Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1567-9530
Hsien-Wei Yeh *Department of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9023-776X
Jooyoung ParkDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Hansol LeeDepartment of Biological Sciences, KAIST Institute for the Biocentury, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.ORCID http://orcid.org/0000-0001-8725-3710
Robert A LanganDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Scott E BoykenDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5378-0632
Marc J LajoieDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Longxing CaoDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Cameron M ChowDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5351-6412
Marcos C MirandaDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.
Jimin WiDepartment of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Hyo Jeong HongDepartment of Systems Immunology, College of Biomedical Science, Kangwon National University, Chuncheon, South Korea.
Lance StewartDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4264-5125
Byung-Ha OhDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA. bhoh@kaist.ac.kr.ORCID http://orcid.org/0000-0002-6437-8470
David BakerDepartment of Biochemistry, Institute for Protein Design, University of Washington, Seattle, WA, USA. dabaker@uw.edu.ORCID http://orcid.org/0000-0001-7896-6217
Funding
Project 4: Novel reagent development to enable molecular characterizationU19AG065156 · NIA · UNIVERSITY OF WASHINGTON · PI MACCOSS, MICHAEL · 2020 to 2024
$15.9MUniversity of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3MNIAID NIH HHS U01 AI151698NIA NIH HHS U19 AG065156
Abstract
Naturally occurring protein switches have been repurposed for the development of biosensors and reporters for cellular and clinical applications
Indexed as
Antibodies, ViralBiosensing TechniquesBotulinum ToxinsCoronavirus M ProteinsCoronavirus Nucleocapsid ProteinsErb-b2 Receptor Tyrosine KinasesHepatitis B virusImmunoglobulin GLimit of DetectionLuminescencePhosphoproteinsProto-Oncogene Proteins c-bcl-2SARS-CoV-2Sensitivity and SpecificitySpike Glycoprotein, CoronavirusTroponin IAntibodies, ViralBCL2L15 protein, humanBotulinum ToxinsCoronavirus M ProteinsCoronavirus Nucleocapsid ProteinsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesImmunoglobulin Gmembrane protein, SARS-CoV-2nucleocapsid phosphoprotein, SARS-CoV-2PhosphoproteinsProto-Oncogene Proteins c-bcl-2Spike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Troponin IViral Matrix Proteins
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.