Evidence map›Paper›PMID 33503592›Full record

ArticlePhysics in medicine and biology2021

Comparison of weekly and daily online adaptation for head and neck intensity-modulated proton therapy.

Mislav Bobić, Arthur Lalonde, Gregory C Sharp, Clemens Grassberger, Joost M Verburg, Brian A Winey, Antony J Lomax, Harald Paganetti

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A systematic review of volumetric image guidance in proton therapy.Physical and engineering sciences in medicine · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mislav BobićDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.ORCID 0000-0002-9409-8680
Arthur LalondeDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.ORCID 0000-0002-8715-8235
Gregory C SharpDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Clemens GrassbergerDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Joost M VerburgDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Brian A WineyDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Antony J LomaxETH Zürich, Zürich, Switzerland.
Harald PaganettiDepartment of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Funding

Fast Individualized Delivery Adaptation in Proton TherapyR01CA229178 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI PAGANETTI, HARALD · 2019 to 2023
$1.5M
NCI NIH HHS R01 CA229178
6 · The paper itself

Abstract

The high conformality of intensity-modulated proton therapy (IMPT) dose distributions causes treatment plans to be sensitive to geometrical changes during the course of a fractionated treatment. This can be addressed using adaptive proton therapy (APT). One important question in APT is the frequency of adaptations performed during a fractionated treatment, which is related to the question whether plan adaptation has to be done online or offline. The purpose of this work is to investigate the impact of weekly and daily online IMPT plan adaptation on the treatment quality for head and neck patients. A cohort of ten head and neck patients with daily acquired cone-beam CT (CBCT) images was evaluated retrospectively. Dose tracking of the IMPT treatment was performed for three scenarios: base plan with no adaptation (BP), weekly online adaptation (OA

Indexed as

Head and Neck NeoplasmsProton TherapyRadiotherapy, Intensity-ModulatedHumansOrgans at RiskRadiotherapy DosageRadiotherapy Planning, Computer-AssistedRetrospective Studiesadaptive radiotherapycone-beam CThead and neck cancerMonte Carloproton therapy

Identifiers

PMID33503592
PMCPMC8313628

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.