ArticleCell reports2021
Sexual and asexual development: two distinct programs producing the same tunicate.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Anatomical and functional organisation of the cholinergic nervous system in the tunicatebioRxiv : the preprint server for biology · 2026Article
- Lifelong Invertebrate Chordate Central Nervous System Regeneration is Driven by a Migrating Pool of Conserved Neural Stem Cells program.bioRxiv : the preprint server for biology · 2026Article
- Multi-stage single-cell atlas of a chordate non-embryonic development unveils dedifferentiating bud founder cells.Nature communications · 2026Article
- Regional signaling controls stem cell-mediated regeneration in an invertebrate chordate.PLoS biology · 2026Article
- Electrical stimulation promotes longevity and regeneration in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Survival Benefits Outweigh Germline Competition Costs in Kin Chimeras.bioRxiv : the preprint server for biology · 2026Article
- Germline stem cell isolation, lineage tracing, and aging in a protochordate.bioRxiv : the preprint server for biology · 2025Article
- Electrical Stimulation Rejuvenates Tunicates: Altered Stem Cell and Immune Activity.bioRxiv : the preprint server for biology · 2025Article
- First chromosome-level genome assembly of the colonial chordate model Botryllus schlosseri (Tunicata).GigaScience · 2025Article
- Speed vs completeness: a comparative study of solitary and colonial tunicate embryogenesis.Frontiers in cell and developmental biology · 2025Article
- Women in tunicate research: Pioneers of the past and their present legacy.Genesis (New York, N.Y. : 2000) · 2023Article
- Stem cell-mediated development, regeneration, chimerism, and aging in the colonial chordate Botryllus schlosseri.Genesis (New York, N.Y. : 2000) · 2023Article
- Multiple Forms of Neural Cell Death in the Cyclical Brain Degeneration of A Colonial Chordate.Cells · 2023Article
- Methods for cell isolation and analysis of the highly regenerative tunicateFrontiers in cell and developmental biology · 2023Article
- Article
- Contributions from both the brain and the vascular network guide behavior in the colonial tunicate Botryllus schlosseri.The Journal of experimental biology · 2022Article
- Two distinct evolutionary conserved neural degeneration pathways characterized in a colonial chordate.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Distinct gene expression dynamics in developing and regenerating crustacean limbs.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Spatially and Temporally Distributed Complexity-A Refreshed Framework for the Study of GRN Evolution.Cells · 2022Article
- Yamanaka Factors in the Budding TunicateFrontiers in cell and developmental biology · 2022Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
Colonial tunicates are the only chordate that possess two distinct developmental pathways to produce an adult body: either sexually through embryogenesis or asexually through a stem cell-mediated renewal termed blastogenesis. Using the colonial tunicate Botryllus schlosseri, we combine transcriptomics and microscopy to build an atlas of the molecular and morphological signatures at each developmental stage for both pathways. The general molecular profiles of these processes are largely distinct. However, the relative timing of organogenesis and ordering of tissue-specific gene expression are conserved. By comparing the developmental pathways of B. schlosseri with other chordates, we identify hundreds of putative transcription factors with conserved temporal expression. Our findings demonstrate that convergent morphology need not imply convergent molecular mechanisms but that it showcases the importance that tissue-specific stem cells and transcription factors play in producing the same mature body through different pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.