Evidence map›Paper›PMID 33503391›Full record

Trial reportAmerican journal of respiratory and critical care medicine2021

Balanced Crystalloids versus Saline in Critically Ill Adults with Hyperkalemia or Acute Kidney Injury: Secondary Analysis of a Clinical Trial.

Alexandra H Toporek, Matthew W Semler, Wesley H Self, Gordon R Bernard, Li Wang, Edward D Siew, Joanna L Stollings, Jonathan P Wanderer, Todd W Rice, Jonathan D Casey and 1 more

Open access · greenAbstract readClinical TrialComparative StudyLetter
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 33 citations in OpenAlex.

  1. Balanced fluid bolus: Should we prefer balanced crystalloids over "normal" saline?Journal of perinatology : official journal of the California Perinatal Association · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Acute kidney injury in patients with burns.Nature reviews. Nephrology · 2024
    Review
  8. Review
  9. Sepsis Management in the Cardiac Intensive Care Unit.Journal of cardiovascular development and disease · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Alexandra H ToporekVanderbilt University Medical Center Nashville, Tennessee.ORCID 0000-0003-0902-0422
Matthew W SemlerVanderbilt University Medical Center Nashville, Tennessee.ORCID 0000-0002-7664-8263
Wesley H SelfVanderbilt University Medical Center Nashville, Tennessee.
Gordon R BernardVanderbilt University Medical Center Nashville, Tennessee.
Li WangVanderbilt University Medical Center Nashville, Tennessee.
Edward D SiewVanderbilt University Medical Center Nashville, Tennessee.
Joanna L StollingsVanderbilt University Medical Center Nashville, Tennessee.
Jonathan P WandererVanderbilt University Medical Center Nashville, Tennessee.
Todd W RiceVanderbilt University Medical Center Nashville, Tennessee.
Jonathan D CaseyVanderbilt University Medical Center Nashville, Tennessee.ORCID 0000-0002-0977-290X
SMART Investigators and the Pragmatic Critical Care Research Group
Vanderbilt University Medical Center · US

Funding

Vanderbilt Institute for Clinical and Translational Research (VICTR) -Identifying correlates of functional immunity in SARS-CoV-2 convalescent plasmaUL1TR002243 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Paul A. Harris, Wesley H Self · 2017 to 2026
$130.7M
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4M
The Vanderbilt Emergency Care Research Training ProgramK12HL133117 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STORROW, ALAN B · 2016 to 2020
$1.9M
Bag-Mask Ventilation to PreVent Hypoxemia during Tracheal Intubation in the Emergency Department: A Clinical TrialK23HL153584 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASEY, JONATHAN DALE · 2020 to 2024
$900k
Oxygen Saturation Targets during Mechanical Ventilation of Critically Ill Adults: A Clinical TrialK23HL143053 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SEMLER, MATTHEW WALL · 2018 to 2022
$854k
Citrulline to Prevent or Mitigate Acute Lung Injury in Severe SepsisR34HL105869 · NHLBI · VANDERBILT UNIVERSITY · PI RICE, TODD W · 2012 to 2014
$686k
NCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002243NHLBI NIH HHS K12 HL133117NHLBI NIH HHS K23 HL143053NHLBI NIH HHS K23 HL153584NHLBI NIH HHS R34 HL105869
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Critical CareFluid TherapyAcute Kidney InjuryAdultAgedCrystalloid SolutionsHumansHyperkalemiaMiddle AgedCrystalloid Solutions

Identifiers

PMID33503391
PMCPMC8456473
OpenAlexW3124527499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.