SynthesisPloS one2021
A systematic review and meta-analysis reveal that Campylobacter spp. and antibiotic resistance are widespread in humans in sub-Saharan Africa.
Synthesis in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Prevalence and determinants of Campylobacter infection in under-five children of East Africa: systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- A systematic review of the methodological considerations in Campylobacter burden of disease studies.PLoS neglected tropical diseases · 2025Pooled it
- Antimicrobial resistance in community-acquired enteric pathogens among children aged ≤ 10-years in low-and middle-income countries: a systematic review and meta-analysis.Frontiers in microbiology · 2025Pooled it
- Article
- Science diplomacy, research and global health.Nature microbiology · 2026Article
- Prevalence and Patterns of Enteric Co-Infections Among Individuals Presenting with Cholera-like Diarrheal Disease During Seasonal Cholera Outbreaks.Pathogens (Basel, Switzerland) · 2025Article
- The Economic and Public Health Burden of Foodborne Illness in Somalia: Prevalence, Costs, and Policy Imperatives.Public health challenges · 2025Article
- High prevalence of antibiotic resistant Campylobacter among patients attending clinical settings in Kigali, Rwanda.BMC infectious diseases · 2025Article
- Azithromycin treatment response as a probe to attribute bacterial etiologies of diarrhea using molecular diagnostics: a reanalysis of the Antibiotics for Children with Severe Diarrhea (ABCD) trial.Frontiers in microbiology · 2025Article
- Study the Antimicrobial Resistance and Virulence Factors of Campylobacter Jejuni and Campylobacter Coli Isolated from Poultry Meat : Campylobacter in poultry meat.Galen medical journal · 2025Article
- Antimicrobial susceptibility profiles of thermophilicFrontiers in microbiology · 2025Article
- Culture-Based Standard Methods for the Isolation ofPolish journal of microbiology · 2024Review
- Burden and epidemiology of Campylobacter species in acute enteritis cases in Burkina Faso.BMC infectious diseases · 2024Article
- Molecular Responses of the Eukaryotic Cell Line INT407 on the InternalizedPathogens (Basel, Switzerland) · 2024Article
- Extent of Virulence and Antibiotic Resistance Genes in Helicobacter pylori and Campylobacteria.Current microbiology · 2024Article
- Genomic diversity of Campylobacter jejuni and Campylobacter coli isolated from the Ethiopian dairy supply chain.PloS one · 2024Article
- Campylobacter in Africa - A specific viewpoint.European journal of microbiology & immunology · 2023Review
- Investigating the Significance of Non-Healthcare (Basel, Switzerland) · 2023Article
- Situational analysis of antimicrobial resistance, laboratory capacities, surveillance systems and containment activities in Ethiopia: A new and one health approach.One health (Amsterdam, Netherlands) · 2023Review
- Susceptibility antibiotic screening reveals high rates of multidrug resistance of Salmonella, Shigella and Campylobacter in HIV infected and uninfected patients from Mozambique.BMC infectious diseases · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionCampylobacter spp. are zoonotic bacteria that cause gastroenteritis in humans worldwide, whose main symptom is diarrhea. In certain cases, extra intestinal manifestations may occur, such as Guillain Barré syndrome. The bacteria cause severe diarrhea mostly in children and in immunocompromised individuals. This review aims to address the prevalence of Campylobacter spp. in humans in sub-Saharan Africa. It also aims to understand the impact of HIV in the prevalence, as well as to report data on antibiotic resistance and propose research priorities.
methodsWe followed PRISMA guidelines to find studies on the occurrence of Campylobacter spp. in humans in all countries from sub-Saharan Africa. Studies published between 2000 and 2020 were searched in PubMed, Cochrane Library, CINAHL, African Index Medicus, African Journals Online, Google Scholar and Science Direct. We have conducted a random-effect meta-analysis and calculated the proportion of resistant isolates to different antibiotics. RESULTS AND DISCUSSION: We found 77 studies that described such occurrence in humans in 20 out of 53 sub-Saharan African countries. Campylobacter jejuni was the most prevalent species. Pooled prevalence was 9.9% (CI: 8.4%-11.6%). No major variations within the different sub-regions were found. Most studies reported Campylobacter spp. as the cause of diarrhea, mainly in children. Some studies reported the bacteria as a possible etiologic agent of acute flaccid paralysis and urinary tract infection. Campylobacter spp. presented a higher pooled prevalence in HIV infected patients, although not statistically significant. High proportions of resistant strains were reported for many antibiotics, including erythromycin and tetracycline.
conclusionCampylobacter spp. occur in sub-Saharan Africa, although information is scarce or inexistent for many countries. Research priorities should include investigation of the understudied species; extra intestinal manifestations; the impact of HIV infection and associated risk factors. Control strategies should be reinforced to contain the spread of this pathogen and drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.