ArticleJournal of cancer survivorship : research and practice2021
Severe reflux, sleep disturbances, and health-related quality of life after esophageal cancer surgery.
Article in Journal of cancer survivorship : research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the prevalence of reflux symptoms after esophagectomy: patient-reported outcomes and management.BMC geriatrics · 2026Pooled it
- Clinical predictors of early reflux and symptom severity after esophagectomy: a risk prediction tool.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Evidence summary on management strategies for gastroesophageal reflux symptoms in patients following esophageal cancer surgery.Asia-Pacific journal of oncology nursing · 2025Review
- Survey on and analysis of the factors influencing the postoperative sleep quality of Chinese patients with oesophageal cancer.World journal of surgical oncology · 2025Article
- Exploring the impact of physical exercise regimens on health-related quality of life following oesophageal or gastric cancer surgery: a systematic review and meta-analysis of randomized controlled trials.BMC sports science, medicine & rehabilitation · 2025Article
- Focusing on the process: experiences and needs of Chinese post-esophagectomy patients and caregivers regarding home enteral nutrition.Frontiers in nutrition · 2025Article
- Examining the factor structure of the Pittsburgh Sleep Quality Index and its determinants among GI cancer patients.BMC cancer · 2024Article
- Reliability and validity of the cancer-related dysfunctional beliefs and attitudes about sleep scale in cancer patients.BMC psychiatry · 2024Article
- Poor Sleep Quality and Its Influencing Factors Among Iranian Patients with Esophageal and Gastric Cancer.Middle East journal of digestive diseases · 2024Article
- Quality of Life and Independent Factors Associated with Poor Digestive Function after Ivor Lewis Esophagectomy.Cancers · 2023Article
- The association between sleep problems and general quality of life in cancer patients and in the general population.Frontiers in psychology · 2022Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeEsophagectomy for cancer is an extensive procedure often followed by severe complications. This study investigated whether patients with severe symptoms of reflux are more likely to have sleep disturbances and reduced health-related quality of life (HRQL) after esophagectomy.
methodsThis Swedish nationwide prospective cohort study encompassed all patients who had undergone esophagectomy for cancer between 2013 and 2018. One year after surgery, the patients responded to three questionnaires on reflux (EORTC QLQOG25), sleep disturbances (KSQ), and HRQL (EORTC QLQ-C30). Multivariable logistic regression provided odds ratios (OR) with 95% confidence intervals (CI) for sleep disturbance/reduced HRQL between patients with and without reflux, adjusted for potential confounders.
resultsAmong 241 esophagectomy patients, 66 (27%) reported severe reflux. Patients with reflux had an increased risk of sleep disturbances (OR 2.3, 95% CI: 1.3-4.3) compared to patients without reflux. More specifically, these patients were more likely to suffer from poor sleep quality (OR 4.9, 95% CI: 1.9-12.4). Patients with reflux and sleep disturbances reported reductions in global quality of life, role function, emotional function, social function, and more symptoms in all scales, except for dyspnea.
conclusionsThis study suggests that patients with severe symptoms of reflux after esophagectomy have an increased risk of sleep disturbances and poor sleep quality, which in turn are associated with reduced HRQL. IMPLICATIONS FOR CANCER SURVIVORS: Alleviating reflux after oesophageal cancer surgery is important, since this common symptom might reduce HRQL and well-being.
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