Evidence map›Paper›PMID 33502643›Full record

ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2021

Clinical and neurohormonal characteristics in African Americans with neurogenic orthostatic hypotension.

Richard J Giza, Maureen C Farrell, Amy C Arnold, Italo Biaggioni, Cyndya A Shibao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Factors contributing to racial differences in neurogenic orthostatic hypotension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Richard J GizaDrexel University College of Medicine, Philadelphia, PA, USA.
Maureen C FarrellDrexel University College of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-4728-0233
Amy C ArnoldDepartment of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID http://orcid.org/0000-0002-1380-6017
Italo BiaggioniDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 506 Robinson Research Building, Nashville, TN, 37232-6602, USA.ORCID http://orcid.org/0000-0001-7667-7083
Cyndya A ShibaoDepartment of Medicine, Division of Clinical Pharmacology, Vanderbilt Autonomic Dysfunction Center, Vanderbilt University Medical Center, 506 Robinson Research Building, Nashville, TN, 37232-6602, USA. Cyndya.shibao@vanderbilt.edu.ORCID http://orcid.org/0000-0002-4518-6801
Drexel University · USVanderbilt University Medical Center · USPennsylvania State University · US

Funding

ROLE OF CD36 IN NUTRIENT DELIVERY AND ITS DYSFUNCTION IN AFRICAN AMERICANSR01DK111175 · NIDDK · WASHINGTON UNIVERSITY · PI ABUMRAD, NADA A., ABUMRAD, NAJI N · 2016 to 2019
$1.9M
Obesity hypertension in African American women: Neuro-metabolic mechanismsK23HL103976 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHIBAO, CYNDYA ADRIANA · 2010 to 2014
$760k
FDA HHS R01 FD004778NHLBI NIH HHS K23 HL103976NIDDK NIH HHS R01 DK111175
6 · The paper itself

Abstract

purposeNeurogenic orthostatic hypotension (nOH) is the hallmark of neurodegenerative forms of autonomic failure, including pure autonomic failure, multiple system atrophy, and Parkinson's disease. Studies have shown autonomic physiological differences in Africans Americans (AA) such as lower heart rate variability, enhanced blood pressure reactivity, and blunted sympathetic neural response compared to non-Hispanic whites. However, the clinical characteristics and neurohormonal profile of autonomic failure in AA is unknown.

methodsA total of 65 patients with nOH participated in this study (9 AA and 56 non-Hispanic whites). Both groups were of similar age and comorbidity status, and they underwent standardized autonomic testing and assessment of neurohormonal levels and renin activity and aldosterone in supine and upright positions.

resultsThere were no significant differences in baseline autonomic clinical characteristics between non-Hispanic whites and AA with nOH. Non-Hispanic whites demonstrated a significant increase in upright renin activity compared to AA (295 ± 88% vs. 13 ± 13%, respectively). AA showed a blunted increase in aldosterone compared to non-Hispanic whites (188 ± 27% vs. 59 ± 38%, respectively). These results indicated persistent suppression of the renin-angiotensin system in AA, particularly during upright posture.

conclusionOur findings demonstrate that AA with nOH have similar clinical characteristics and hemodynamic autonomic profiles, but lower upright renin activity and aldosterone levels, compared to non-Hispanic whites. Renin suppression persists in AA with severe autonomic failure and can potentially contribute to postural changes and supine hypertension.

Indexed as

Autonomic Nervous System DiseasesHypertensionHypotension, OrthostaticBlack or African AmericanBlood PressureHumansAfrican AmericansAldosteroneAutonomic failureNeurogenic orthostatic hypotensionPlasmaRenin activity

Identifiers

PMID33502643
PMCPMC9014397
OpenAlexW3123049949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.