Evidence map›Paper›PMID 33502641›Full record

ArticleNeurosurgical review2021

Low-dose antiplatelet therapy survey after intracerebral hemorrhage in China: a retrospective hospital-based study.

Xiangke Ma, Dongtao Liu, Siqiang Niu, Wei Zhao, Xifang Song, Changqing Li, Lichun Zhou, Jing Ma, Weihua Jia

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Xiangke Ma *Department of Neurosurgery, Beijing Chaoyang Hospital, Capital Medical University, No. 5 Jingyuan Road, Beijing, 100043, China. maxiangke08@163.com.ORCID http://orcid.org/0000-0002-5878-0287
Dongtao Liu *Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 5 Jingyuan Road, Beijing, 100043, China.
Siqiang NiuDepartment of Neurosurgery, Linyi People's Hospital, No. 105, Guangchang Street, Dezhou City, 251500, Shandong Province, China.
Wei ZhaoDepartment of Echocardiography, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Xifang SongDepartment of Echocardiography, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Changqing LiDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 5 Jingyuan Road, Beijing, 100043, China.
Lichun ZhouDepartment of Neurology, Beijing Chaoyang Hospital, Capital Medical University, No. 5 Jingyuan Road, Beijing, 100043, China.
Jing MaDepartment of Echocardiography, Shanghai Xuhui Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai, China.
Weihua JiaDepartment of Neurology, Shijingshan Teaching Hospital, Beijing Shijingshan Hospital, Capital Medical University, No. 24, Shijingshan Road, Beijing, 100041, China. jwh1973@163.com.
Capital Medical University · CNFudan University · CNLinyi People's Hospital · CN

Funding

National Natural Science Foundation of China 81501483Natural Science Foundation of Shanghai 18ZR1435400Wu Jieping Medical Foundation 320.675.1279
6 · The paper itself

Abstract

Restarting of antiplatelet therapy (AT) for patients with a history of intracerebral hemorrhage (ICH) is still a clinical dilemma in China. We aimed to investigate the association between low-dose AT and the long-term clinical outcome in Chinese ICH patients. A total of 312 patients with a history of ICH were retrospectively enrolled and followed. The ischemic vascular events, recurrent ICH, and all-cause death were reviewed retrospectively. We explored the predictors of ischemic vascular events and recurrent ICH from all patients using Cox proportional hazard regression model. One hundred fifty-one (48.4%) patients were treated with low-dose AT, and the median duration of follow-up was 4.0 years (interquartile range, 2.5-5 years). Compared to 30 (19.8%) of 151 participants who restarted low-dose AT had ischemic vascular events, 51 (31.7%) of 161 participants who did not receive AT showed ischemic vascular events (p=0.025). Eighteen (11.9%) of 151 participants treated with low-dose AT had recurrent ICH and 21 (13.0%) of 161 in non-AT participants (p=0.830). Cox regression analysis also showed that diabetes mellitus was an independent risk factor for ischemic vascular events (p=0.029). Uncontrolled blood pressure (BP) was independently associated with the risk for both ischemic vascular events (p=0.025) and recurrent ICH (p=0.001). Atrial fibrillation (AF) was an independent risk factor for recurrent ICH among patients with a history of ICH (p=0.018). In a Chinese population of patients with predominantly deep, mild to moderate severity ICH, restarting of low-dose AT at a median of 6.2 months was associated with a lower risk of ischemic vascular events without increased risk of recurrent ICH.

Indexed as

Platelet Aggregation InhibitorsStrokeCerebral HemorrhageChinaHospitalsHumansRetrospective StudiesRisk FactorsPlatelet Aggregation InhibitorsAntiplateletIntracerebral hemorrhageIschemic vascular eventsRecurrent intracerebral hemorrhage

Identifiers

PMID33502641
OpenAlexW3123756564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.