Evidence map›Paper›PMID 33502605›Full record

ArticleCell and tissue research2021

Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway.

Wei Sun, Zhe Wang, Min Sun, Weixin Huang, Yimeng Wang, Yuehui Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Cell and tissue research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 38 citations in OpenAlex.

  1. Cardioprotective Effects ofLife (Basel, Switzerland) · 2026
    Review
  2. Hormesis: induction byOpen medicine (Warsaw, Poland) · 2026
    Review
  3. Signaling Pathways and Therapeutic Approaches in Post-Myocardial Infarction Fibrosis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Frontiers in pharmacology · 2025
    Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Aloin Attenuates Oxidative Stress, Inflammation, and CClJournal of agricultural and food chemistry · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wei Sun *Department of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China.
Zhe Wang *Department of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China.
Min SunDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China.
Weixin HuangDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China.
Yimeng WangDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China.
Yuehui WangDepartment of Geriatrics, The First Hospital of Jilin University, Changchun, Jilin, 130021, P.R. China. Wangyuehuijilin@126.com.ORCID http://orcid.org/0000-0002-1429-6899
Jilin University · CN

Funding

Jilin Province Science and Technology Development Project 20190701007GHthe National Science Foundation of China 81671378
6 · The paper itself

Abstract

Myocardial ischemia/reperfusion injury (I/RI) frequently incurs in acute myocardial infarction with high morbidity and mortality worldwide and is characterized with cardiomyocyte apoptosis and inflammatory response. Aloin is a major anthraquinone from Aloe species and fulfills pleiotropic protective functions in several disease models including hepatic injury. Nevertheless, the potential of aloin in MI/RI remains elusive. Intriguingly, aloin had modest cytotoxicity in H9c2 cardiomyocytes. Importantly, aloin dose-dependently ameliorated cell viability that was inhibited in response to simulated ischemia/reperfusion (SI/R) stimulation. Moreover, the enhanced apoptosis in cells under SI/R conditions were reduced after aloin treatment, concomitant with the decrease in pro-apoptotic Bax protein levels and increase in anti-apoptotic Bcl-2 protein expression. Of interest, aloin administration attenuated SI/R-induced oxidant stress by decreasing reactive oxygen species (ROS) production, lactate dehydrogenase (LDH), and malondialdehyde (MDA) release and increasing activity of anti-oxidant stress enzyme superoxide dismutase (SOD). Additionally, the elevated pro-inflammatory cytokine levels were counteracted after aloin treatment in cells under SI/R conditions, including TNF-α, IL-6, and IL-1β. Mechanically, aloin further enforced the activation of the NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling. Noticeably, blockage of this pathway by si-Nrf2 transfection blunted aloin-mediated cardioprotective efficacy against SI/R-evoked oxidative stress injury and inflammatory response. Thus, these findings corroborate that aloin may antagonize SI/R-induced cardiomyocyte injury by attenuating excessive oxidative stress and inflammation, thereby endorsing its potential as a promising therapeutic agent against myocardial infarction.

Indexed as

AnimalsCell LineEmodinHeme Oxygenase-1InflammationMyocytes, CardiacNF-E2-Related Factor 2Oxidative StressProtective AgentsRatsReperfusion InjuryalloinEmodinHeme Oxygenase-1Nfe2l2 protein, ratNF-E2-Related Factor 2Protective AgentsAloinCardiomyocytesInflammatory responseInjuryIschemia/reperfusionNrf2-HO-1 axisRadiation-induced pulmonary fibrosis

Identifiers

PMID33502605
OpenAlexW3124086908

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.