Evidence map›Paper›PMID 33502559›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2021

Development of the Asia Pacific Consortium on Osteoporosis (APCO) Framework: clinical standards of care for the screening, diagnosis, and management of osteoporosis in the Asia-Pacific region.

M Chandran, P J Mitchell, T Amphansap, S K Bhadada, M Chadha, D-C Chan, Y-S Chung, P Ebeling, N Gilchrist, A Habib Khan and 19 more

Erratum issuedAbstract read
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Guideline
  2. Prevalence of osteoporosis and incidence of related fractures in developed economies in the Asia Pacific region: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023
    Pooled it
  3. Guideline
  4. Article
  5. Regional data, global lessons: what the Asia-Pacific osteoporosis audit teaches the world.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  6. Consensus statement on the application of artificial intelligence in osteoporosis screening and management: perspectives from the Asia-Pacific region.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  7. Article
  8. Article
  9. Clinical and economic impact of deep learning-enhanced opportunistic osteoporosis screening using chest radiographs with and without the osteoporosis self-assessment tool for Asians (OSTA).Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026
    Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
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  18. Article
  19. Secondary fracture prevention in primary care: a narrative review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2024
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

M ChandranDepartment of Endocrinology, Osteoporosis and Bone Metabolism Unit, Singapore General Hospital, 20, College Road, Academia, Singapore, 169856, Singapore. manju.chandran@singhealth.com.sg.ORCID https://orcid.org/0000-0001-9119-8443
P J MitchellSynthesis Medical NZ Limited, Pukekohe, Auckland, New Zealand.ORCID https://orcid.org/0000-0002-7439-0369
T AmphansapDepartment of Orthopedics, Police General Hospital, Bangkok, Thailand.ORCID https://orcid.org/0000-0003-2148-3921
S K BhadadaDepartment of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
M ChadhaDepartment of Endocrinology, Hinduja Hospital and Research Centre, Mumbai, India.
D-C ChanInternal Medicine, National University Hospital Chu-Tung Branch, Chinese Taipei, Taiwan.
Y-S ChungDepartment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.ORCID https://orcid.org/0000-0003-0179-4386
P EbelingDepartment of Medicine in the School of Clinical Sciences, Monash Health, Melbourne, Australia.
N GilchristCanterbury District Health Board, Christchurch, New Zealand.
A Habib KhanSection of Chemical Pathology, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan.ORCID https://orcid.org/0000-0001-7693-5740
P HalboutInternational Osteoporosis Foundation, Nyon, Switzerland.
F L HewDepartment of Medicine, Subang Jaya Medical Centre, Subang Jaya, Malaysia.
H-P T LanMusculoskeletal and Metabolic Unit, Biomedical Research Center, Pham Ngoc Thach University of Medicine, Bone and Muscle Research Group, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
T C LauDivision of Rheumatology, Department of Medicine, National University Hospital, Singapore, Singapore.
J K LeeDepartment of Orthopedics, Beacon International Specialist Centre, Petaling Jaya, Malaysia.
S LekamwasamFaculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
G LyubomirskyOsteoporosis Australia, Sydney, Australia.
L B Mercado-AsisFaculty of Medicine and Surgery, University of Santo Tomas, Manila, Philippines.
A MithalEndocrinology, Diabetes Division, Mithal, M. Max Healthcare - Pan-Max, Gurgaon, India.
T V NguyenGenetics and Epidemiology of Osteoporosis Laboratory, Bone Biology Division, Garvan Institute of Medical Reseach, Sydney, Australia.
D PandeyDepartment of Orthopaedics, National Trauma Centre, Kathmandu, Nepal.
I R ReidFaculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
A SuzukiDepartment of Endocrinology, School of Medicine, Fujita Health University, Toyoake, Japan.
T T ChitEast Yangon General Hospital, Yangon, Myanmar.
K L TiuPolytrauma and Fragility Fracture team, Department of Orthopaedics and Traumatology, Queen Elizabeth Hospital, Hong Kong, SAR, China.
T ValleenukulDepartment of Orthopedics, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
C K YungDepartment of Endocrinology and Patient Safety Unit, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam.
Y L ZhaoDepartment of Obstetrics and Gynecology, Beijing United Family Hospital, Beijing, China.
Asia Pacific Consortium on Osteoporosis (APCO)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Guidelines for doctors managing osteoporosis in the Asia-Pacific region vary widely. We compared 18 guidelines for similarities and differences in five key areas. We then used a structured consensus process to develop clinical standards of care for the diagnosis and management of osteoporosis and for improving the quality of care. PURPOSE: Minimum clinical standards for assessment and management of osteoporosis are needed in the Asia-Pacific (AP) region to inform clinical practice guidelines (CPGs) and to improve osteoporosis care. We present the framework of these clinical standards and describe its development.

methodsWe conducted a structured comparative analysis of existing CPGs in the AP region using a "5IQ" model (identification, investigation, information, intervention, integration, and quality). One-hundred data elements were extracted from each guideline. We then employed a four-round Delphi consensus process to structure the framework, identify key components of guidance, and develop clinical care standards.

resultsEighteen guidelines were included. The 5IQ analysis demonstrated marked heterogeneity, notably in guidance on risk factors, the use of biochemical markers, self-care information for patients, indications for osteoporosis treatment, use of fracture risk assessment tools, and protocols for monitoring treatment. There was minimal guidance on long-term management plans or on strategies and systems for clinical quality improvement. Twenty-nine APCO members participated in the Delphi process, resulting in consensus on 16 clinical standards, with levels of attainment defined for those on identification and investigation of fragility fractures, vertebral fracture assessment, and inclusion of quality metrics in guidelines.

conclusionThe 5IQ analysis confirmed previous anecdotal observations of marked heterogeneity of osteoporosis clinical guidelines in the AP region. The Framework provides practical, clear, and feasible recommendations for osteoporosis care and can be adapted for use in other such vastly diverse regions. Implementation of the standards is expected to significantly lessen the global burden of osteoporosis.

Indexed as

OsteoporosisSpinal FracturesAsiaHumansMass ScreeningStandard of CareAsia-PacificConsensusGuidelinesOsteoporosisStandards of care

Identifiers

PMID33502559
PMCPMC8192320

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.