Evidence map›Paper›PMID 33502531›Full record

Observational studyThe Journal of infectious diseases2021

Comparison of Capillary Versus Venous Blood for the Diagnosis of Plasmodium falciparum Malaria Using Rapid Diagnostic Tests.

Abalinda M Gorret, Rabbison Muhindo, Emma Baguma, Moses Ntaro, Edgar M Mulogo, Molly Deutsch-Feldman, Jonathan J Juliano, Dan Nyehangane, Ross M Boyce

Abstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Journal of infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Observational
  2. Detection ofDiagnostics (Basel, Switzerland) · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abalinda M GorretDepartment of Medical Laboratory Science, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Rabbison MuhindoDepartment of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Emma BagumaDepartment of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Moses NtaroDepartment of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Edgar M MulogoDepartment of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Molly Deutsch-FeldmanDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jonathan J JulianoDivision of Infectious Diseases, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Dan NyehanganeDepartment of Medical Laboratory Science, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Ross M BoyceDepartment of Community Health, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.ORCID 0000-0002-9489-6324

Funding

Mentoring in Translational Malaria GenomicsK24AI134990 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jonathan J Juliano · 2018 to 2026
$1.6M
Serial Killers to Mosquitos: The Spatial Targeting of Larval habitats in rural Uganda using geographic ProfilingK23AI141764 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BOYCE, ROSS MATHEW · 2019 to 2023
$944k
NIAID NIH HHS K23 AI141764NIAID NIH HHS K24 AI134990
6 · The paper itself

Abstract

We enrolled 250 febrile children in western Uganda to compare the results of malaria rapid diagnostic tests (RDTs) when using capillary vs venous blood. Participants were tested with 4 different RDT types. Polymerase chain reaction testing was performed as the reference standard. Sensitivity and specificity were broadly similar across RDT types and sampling method. Agreement between sample type was high, ranging from 0.95 to 0.99. When following the manufacturer's recommended interpretation, only 5 tests would have resulted in a different clinical diagnosis. These results demonstrate that malaria RDTs perform similarly when using capillary or venous blood in febrile children with Plasmodium falciparum malaria.

Indexed as

CapillariesChildChild, PreschoolFemaleHumansMalaria, FalciparumMalePolymerase Chain ReactionProspective StudiesSensitivity and SpecificityVeinsdiagnostic testmalariaPlasmodium

Identifiers

PMID33502531
PMCPMC8491838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.