Evidence map›Paper›PMID 33502530›Full record

Observational studyThe Journal of infectious diseases2022

Long-term Memory Response After a Single Intramuscular Rabies Booster Vaccination 10-24 Years After Primary Immunization.

Cornelis A De Pijper, Annefleur C Langedijk, Sanne Terryn, Steven Van Gucht, Martin P Grobusch, Abraham Goorhuis, Cornelis Stijnis

Abstract readObservational Study
In one paragraph

Observational study in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
  2. Review
  3. Rabies post-exposure prophylaxis in India: a SWOT analysis.Therapeutic advances in vaccines and immunotherapy · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Monoclonal antibody applications in travel medicine.Tropical diseases, travel medicine and vaccines · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cornelis A De PijperAmsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands.ORCID 0000-0001-5036-4724
Annefleur C LangedijkAmsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands.
Sanne TerrynNational Reference Center of Rabies, Viral Diseases, Infectious Diseases in Humans, Sciensano, Brussels, Belgium.
Steven Van GuchtNational Reference Center of Rabies, Viral Diseases, Infectious Diseases in Humans, Sciensano, Brussels, Belgium.
Martin P GrobuschAmsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands.
Abraham GoorhuisAmsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands.
Cornelis StijnisAmsterdam University Medical Centers, University of Amsterdam, Division of Internal Medicine, Department of Infectious Diseases, Center for Tropical Medicine and Travel Medicine, Amsterdam Infection and Immunity, Amsterdam Public Health, Amsterdam, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPublished data regarding long-lasting immunological rabies memory after pre-exposure prophylaxis (PrEP) are scarce. We tested the hypothesis that rabies booster immunization elicits rapid anamnestic responses.

methodsFor this observational study, we included participants who had received PrEP 10-24 years before inclusion. We measured rabies antibody titers before, and on days 3, 7, and 14 after a single intramuscular booster.

resultsAll 28 participants responded adequately regardless of route of administration or 2-dose vs 3-dose PrEP regimen.

conclusionRabies immunological memory is reactivated within 7 days after a single intramuscular booster immunization, even when administered 10-24 years after PrEP.

Indexed as

RabiesRabies VaccinesRabies virusAntibodies, ViralHumansImmunization, SecondaryInjections, IntradermalInjections, IntramuscularMemory, Long-TermVaccinationAntibodies, ViralRabies Vaccinesboostabilitybooster immunizationimmunizationlong-term immunogenicity datapost-exposure prophylaxisrabies

Identifiers

PMID33502530
PMCPMC9492309

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.