Evidence map›Paper›PMID 33502020›Full record

ArticleAmerican journal of hematology2021

Genomic characteristics and prognostic significance of co-mutated ASXL1/SRSF2 acute myeloid leukemia.

Daniel R Richardson, David M Swoboda, Dominic T Moore, Steven M Johnson, Onyee Chan, Jonathan Galeotti, Sonia Esparza, Mohammad O Hussaini, Hendrick Van Deventer, Matthew C Foster and 4 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in American journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Epigenetic regulation by ASXL1 in myeloid malignancies.International journal of hematology · 2023
    Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Daniel R RichardsonLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0001-9310-5773
David M SwobodaDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.ORCID 0000-0002-6102-1695
Dominic T MooreLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Steven M JohnsonDepartment of Pathology and Laboratory Medicine, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Onyee ChanDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Jonathan GaleottiDepartment of Pathology and Laboratory Medicine, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Sonia EsparzaLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Mohammad O HussainiDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Hendrick Van DeventerLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Matthew C FosterLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Catherine C CoombsLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
Nathan D MontgomeryLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0003-1765-6623
David A SallmanDepartment of Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA.
Joshua F ZeidnerLineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.ORCID 0000-0002-9014-1514
University of North Carolina at Chapel Hill · USMoffitt Cancer Center · US

Funding

AHRQ HHS T32 HS000032NCI NIH HHS L30 CA264755
6 · The paper itself

Abstract

The ASXL1 and SRSF2 mutations in AML are frequently found in patients with preexisting myeloid malignancies and are individually associated with poor outcomes. In this multi-institutional retrospective analysis, we assessed the genetic features and clinical outcomes of 43 patients with ASXL1

Indexed as

MutationAdultAgedAged, 80 and overAllelesCell Transformation, NeoplasticCocarcinogenesisFemaleHigh-Throughput Nucleotide SequencingHumansKaplan-Meier EstimateLeukemia, Myeloid, AcuteMaleMiddle AgedPrognosisRepressor ProteinsASXL1 protein, humanRepressor ProteinsSerine-Arginine Splicing FactorsSRSF2 protein, human

Identifiers

PMID33502020
PMCPMC10284351
OpenAlexW3123292421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.