Evidence map›Paper›PMID 33502012›Full record

ArticleImmunology2021

Inducible ablation of CD11c

Zhi Li, Rebecca Lamb, Mark C Coles, Clare L Bennett, Carrie A Ambler

Abstract read
In one paragraph

Article in Immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Apoptosis and Cell Clearance in Skin Wound Healing.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Article
  8. Skin immunity in wound healing and cancer.Frontiers in immunology · 2023
    Review
  9. Platelet Derivatives and the Immunomodulation of Wound Healing.International journal of molecular sciences · 2022
    Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Traumatic Brain Injury Induces Early Barrier Protective Responses in Incisional Skin Wounds Accelerating Cutaneous Wound Healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Zhi LiDepartment of Biosciences, Biophysical Sciences Institute, Durham University, Durham, UK.ORCID 0000-0002-0583-1116
Rebecca LambDepartment of Biosciences, Biophysical Sciences Institute, Durham University, Durham, UK.
Mark C ColesDepartment of Biology, Centre for Immunology and Infection, Hull York Medical School, York, UK.
Clare L BennettInstitute of Immunity and Transplantation, University College London, London, UK.
Carrie A AmblerDepartment of Biosciences, Biophysical Sciences Institute, Durham University, Durham, UK.ORCID 0000-0002-2697-7376

Funding

BBSRC BB/L001608/1Medical Research Council MR/K021125/1
6 · The paper itself

Abstract

Whether resident and recruited myeloid cells may impair or aid healing of acute skin wounds remains a debated question. To begin to address this, we examined the importance of CD11c+ myeloid cells in the early activation of skin wound repair. We find that an absence of CD11c+ cells delays wound closure and epidermal proliferation, likely due to defects in the activation of the IL-23-IL-22 axis that is required for wound healing.

Indexed as

Wound HealingAnimalsCD11 AntigensDendritic CellsDisease Models, AnimalKineticsLangerhans CellsMiceMice, Inbred C57BLMice, TransgenicSkinWounds and InjuriesCD11 AntigensItgax protein, mouseCD11cdendritic cellsLangerhans cellsskinwound repair

Identifiers

PMID33502012
PMCPMC8044329

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.