ReviewPerspectives on psychological science : a journal of the Association for Psychological Science2021
Psychological and Behavioral Predictors of Vaccine Efficacy: Considerations for COVID-19.
Review in Perspectives on psychological science : a journal of the Association for Psychological Science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
100 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy of novel SARS-CoV2 vaccines in preventing SARS- CoV- 2 infection: a systematic review and meta-analysis.BMC infectious diseases · 2025Pooled it
- Axes of social inequities in COVID-19 clinical trials: A systematic review.Frontiers in public health · 2023Pooled it
- Immune response to vaccination in adults with mental disorders: A systematic review.Journal of affective disorders · 2022Pooled it
- Breast cancer survivors' typhoid vaccine responses: Chemotherapy, obesity, and fitness make a difference.Brain, behavior, and immunity · 2022Trial
- Stress and the Immune System: Insights From Psychoneuroimmunology.Physiological research · 2026Review
- Adaptive immune responses to vaccination reflect social status at first exposure in female rhesus macaques.bioRxiv : the preprint server for biology · 2026Article
- Dissociable impacts of physical and psychological factors on side effects after COVID-19 vaccination in Japan: A within-subject repeated measures design.BMC psychology · 2025Article
- The association between depressive symptoms and antibody response following SARS-CoV-2 vaccination among central North Carolina residents.PLOS mental health · 2025Article
- Vaccine hesitancy and decision regret among nurses in oncology settings in Italy: a cluster-based profile analysis.Scientific reports · 2025Article
- Mental health issues, coping mechanisms, and COVID-19 vaccine acceptance among chronically ill patients in tertiary health facilities in Central Region, Ghana.Discover mental health · 2025Article
- Cross-country assessment of the unique contributions of psychological factors to vaccination: Perspectives on the COVID-19 pandemic.Journal of health psychology · 2025Article
- Using Large Language Models to Assess Burnout Among Health Care Workers in the Context of COVID-19 Vaccine Decisions and Health Beliefs: Retrospective Cohort Study.JMIR nursing · 2025Article
- Illness Expectations and Asthma Symptoms: A 6-Month Longitudinal Study.Health expectations : an international journal of public participation in health care and health policy · 2025Article
- Strategies and resources used by public health units to encourage COVID-19 vaccination among priority groups: a behavioural science-informed review of three urban centres in Canada.BMC public health · 2025Review
- Holistic care in mild upper respiratory tract infections (MURTIs): an approach to individualized care management.Drugs in context · 2025Review
- Post-pandemic insights on COVID-19 and premature ovarian insufficiency.Open life sciences · 2025Review
- Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.Cancers · 2024Article
- How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024Review
- Examining the association of vaccine-related mindsets and post-vaccination antibody response, side effects, and affective outcomes.Brain, behavior, & immunity - health · 2024Article
- Effectiveness of COVID-19 Vaccines in People with Severe Mental Illness: A Systematic Review and Meta-Analysis.Vaccines · 2024Review
40 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine candidates are being evaluated, with the goal of conferring immunity on the highest percentage of people who receive the vaccine as possible. It is noteworthy that vaccine efficacy depends not only on the vaccine but also on characteristics of the vaccinated. Over the past 30 years, a series of studies has documented the impact of psychological factors on the immune system's vaccine response. Robust evidence has demonstrated that stress, depression, loneliness, and poor health behaviors can impair the immune system's response to vaccines, and this effect may be greatest in vulnerable groups such as the elderly. Psychological factors are also implicated in the prevalence and severity of vaccine-related side effects. These findings have generalized across many vaccine types and therefore may be relevant to the SARS-CoV-2 vaccine. In this review, we discuss these psychological and behavioral risk factors for poor vaccine responses, their relevance to the COVID-19 pandemic, as well as targeted psychological and behavioral interventions to boost vaccine efficacy and reduce side effects. Recent data suggest these psychological and behavioral risk factors are highly prevalent during the COVID-19 pandemic, but intervention research suggests that psychological and behavioral interventions can increase vaccine efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.