Evidence map›Paper›PMID 33501887›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2021

Every breath you take: Impacts of environmental dust exposure on intestinal barrier function-from the gut-lung axis to COVID-19.

Meli'sa S Crawford, Tara M Nordgren, Declan F McCole

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Microplastics, nanoplastics and liver disease: an emerging health concern?Nature reviews. Gastroenterology & hepatology · 2026
    Review
  2. Article
  3. Review
  4. SARS-CoV-2 and Environmental Changes: The Perfect Storm.Current issues in molecular biology · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. "Journal of rural studies · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Meli'sa S CrawfordDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, California.
Tara M NordgrenDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, California.
Declan F McColeDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, California.
University of California, Riverside · US

Funding

A NOVEL ROLE FOR PTPN2 IN INTESTINAL EPITHELIAL BARRIER REGULATIONR01DK091281 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Declan McCole · 2012 to 2026
$5.5M
Tyrosine Phosphatase Regulation of Mucosal Macrophage-Epithelial Cell Cross-talkR01AI153314 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI MCCOLE, DECLAN · 2020 to 2024
$2.5M
The role of omega-3 fatty acids and bioactive lipid signaling in airway inflammation and resolution following organic dust exposuresR00ES025819 · NIEHS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NORDGREN, TARA M · 2017 to 2019
$747k
HHS | National Institutes of Health (NIH) 1R01AI153314HHS | National Institutes of Health (NIH) 2R01DK091281HHS | National Institutes of Health (NIH) R00ES025819NIAID NIH HHS R01 AI153314NIDDK NIH HHS R01 DK091281NIEHS NIH HHS R00 ES025819
6 · The paper itself

Abstract

As countries continue to industrialize, major cities experience diminished air quality, whereas rural populations also experience poor air quality from sources such as agricultural operations. These exposures to environmental pollution from both rural and populated/industrialized sources have adverse effects on human health. Although respiratory diseases (e.g., asthma and chronic obstructive pulmonary disease) are the most commonly reported following long-term exposure to particulate matter and hazardous chemicals, gastrointestinal complications have also been associated with the increased risk of lung disease from inhalation of polluted air. The interconnectedness of these organ systems has offered valuable insights into the roles of the immune system and the micro/mycobiota as mediators of communication between the lung and the gut during disease states. A topical example of this relationship is provided by reports of multiple gastrointestinal symptoms in patients with coronavirus disease 2019 (COVID-19), whereas the rapid transmission and increased risk of COVID-19 has been linked to poor air quality and high levels of particulate matter. In this review, we focus on the mechanistic effects of environmental pollution on disease progression with special emphasis on the gut-lung axis.

Indexed as

COVID-19Environmental ExposureGastrointestinal DiseasesLung DiseasesAir PollutionComorbidityDisease ProgressionHumansPublic HealthSARS-CoV-2air pollutionCOVID-19gutintestinal barrierlung

Identifiers

PMID33501887
PMCPMC8054554
OpenAlexW3125700394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.