Evidence map›Paper›PMID 33501878›Full record

ArticleDrug delivery2021

Theoretical model for the diclofenac release from PEGylated chitosan hydrogels.

Daniela Ailincai, Maricel Agop, Ioana Cristina Marinas, Andrei Zala, Stefan Andrei Irimiciuc, Lucian Dobreci, Tudor-Cristian Petrescu, Constantin Volovat

Open access · goldAbstract read
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Daniela AilincaiPetru Poni Institute of Macromolecular Chemistry, Romanian Academy, Iasi, Romania.
Maricel AgopDepartment of Physics, "Gh. Asachi" Technical University of Iasi, Iasi, Romania.
Ioana Cristina MarinasCenter for Services and Research in Advanced Biotechnologies, Calugareni, Sanimed International Impex srl, Bucharest, Romania.
Andrei ZalaMunicipal Emergency Hospital-Moineşti, Moineşti, Romania.
Stefan Andrei IrimiciucNational Institute for Laser, Plasma and Radiation Physics, Bucharest, Romania.
Lucian DobreciDepartment of Physical and Occupational Therapy, Vasile Alecsandri University of Bacau, Bacau, Romania.
Tudor-Cristian PetrescuDepartment of Structural Mechanics, "Gh. Asachi" Technical University of Iasi, Iasi, Romania.
Constantin Volovat"Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Academy of Romanian Scientists · ROGheorghe Asachi Technical University of Iași · ROGrigore T. Popa University of Medicine and Pharmacy · RONational Institute for Laser Plasma and Radiation Physics · RORomanian Academy · ROUniversity of Bacău · RO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Controlled drug delivery systems are of utmost importance for the improvement of drug bioavailability while limiting the side effects. For the improvement of their performances, drug release modeling is a significant tool for the further optimization of the drug delivery systems to cross the barrier to practical application. We report here on the modeling of the diclofenac sodium salt (DCF) release from a hydrogel matrix based on PEGylated chitosan in the context of Multifractal Theory of Motion, by means of a fundamental spinor set given by 2 × 2 matrices with real elements, which can describe the drug-release dynamics at global and local scales. The drug delivery systems were prepared by

Indexed as

ChitosanDrug LiberationHydrogelsModels, TheoreticalPolyethylene GlycolsAcyclic MonoterpenesDiclofenacDrug Delivery SystemsHydrogenationModels, ChemicalAcyclic MonoterpenesChitosancitralDiclofenacHydrogelsPolyethylene Glycolsdiclofenac sodium saltdrug releaselie groupsMultifractal Theory of MotionPEGylated chitosan

Identifiers

PMID33501878
PMCPMC7850333
OpenAlexW3125126530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.