Evidence map›Paper›PMID 33501845›Full record

Trial reportApplied neuropsychology. Child

Working memory training in pediatric brain tumor survivors after recent diagnosis: Challenges and initial effects.

Rachel E Siciliano, Jennifer C Thigpen, Leandra Desjardins, Jessica L Cook, Ellen H Steele, Meredith A Gruhn, Megan Ichinose, Sohee Park, Adam J Esbenshade, Devang Pastakia and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Applied neuropsychology. Child. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rachel E SicilianoDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-5958-6550
Jennifer C ThigpenDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.
Leandra DesjardinsDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-0455-169X
Jessica L CookDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.
Ellen H SteeleDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0002-0106-8803
Meredith A GruhnDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.
Megan IchinoseDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.
Sohee ParkDepartment of Psychology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0003-3797-4776
Adam J EsbenshadeDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Devang PastakiaDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John C WellonsDepartment of Neurosurgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Bruce E CompasDepartment of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee, USA.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

LIFE-SPAN DEVELOPMENT OF NORMAL AND ABNORMAL BEHAVIORT32MH018921 · NIMH · VANDERBILT UNIVERSITY · PI HUMPHREYS, KATHRYN LEIGH · 1989 to 2024
$6.7M
Neuroplasticity-Based Cognitive Remediation for Pediatric Brain Tumor SurvivorsR21CA175840 · NCI · VANDERBILT UNIVERSITY · PI COMPAS, BRUCE E · 2014 to 2015
$364k
NCI NIH HHS R21 CA175840NIMH NIH HHS T32 MH018921
6 · The paper itself

Abstract

Research shows promise for cognitive interventions for children diagnosed with brain tumors. Interventions have been delivered approximately 5 years postdiagnosis on average, yet recent evidence shows cognitive deficits may appear near diagnosis. The present study assessed the feasibility and initial effects of working memory training in children with brain tumors delivered soon after diagnosis and followed 2 years postdiagnosis. Children completed baseline assessments 10 months postdiagnosis and were randomized to complete adaptive or nonadaptive (i.e., control) Cogmed Working Memory Training. Children were administered the WISC-IV Working Memory Index (WMI) and NIH Toolbox Cognitive Battery (NTCB), and parents completed attentional and executive function measures at four time points. On average, participants completed half of prescribed Cogmed sessions. Retention for the three follow-up assessments proved difficult. For both Cogmed groups, WMI and NTCB scores significantly improved immediately postintervention compared to baseline scores. Significant differences were not maintained at the remaining follow-ups. There was preliminary evidence for improved executive function at the final follow-up on parent-reported measures. Working memory training closer to diagnosis proved difficult, though results suggest evidence of cognitive improvement. Future studies should continue to examine potentially efficacious interventions for children with brain tumors and optimal delivery windows to maximize impact.

Indexed as

Brain NeoplasmsMemory, Short-TermChildExecutive FunctionHumansLearningSurvivorsBrain tumorcancercognitioninterventionpediatricworking memory

Identifiers

PMID33501845
PMCPMC11913254
OpenAlexW3125080102

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.