ReviewThe Journal of physiology2022
Physiology of physical inactivity, sedentary behaviours and non-exercise activity: insights from the space bedrest model.
Review in The Journal of physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 74 citations in OpenAlex.
- Differences in cardiorespiratory fitness, physical activity, and pulmonary function across occupational groups and educational levels: a cross-sectional study.Annals of medicine · 2026Article
- Factors Associated with Overweight and Obesity and Their Prevalence Among Medical Students in the Eastern Province of Saudi Arabia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Acute Cognitive Effects of Brief Physical Activity Breaks After Lecture-Based Academic Activity in Undergraduate University Students: A Randomized Crossover Study.Healthcare (Basel, Switzerland) · 2026Article
- Skeletal muscle mass is not compositionally uniform: the role of fluid compartments in health and performance monitoring.European journal of clinical nutrition · 2026Review
- Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Longer sedentary time is associated with increased risk of low pelvic bone density.BMC public health · 2026Article
- The Effects of Multi-Theory Model-Based Behavior Change Intervention with Staircase Approach on Sedentary Lifestyle Among Community-Dwelling Older Adults: Study Protocol for a Randomized Controlled Trial.JMIR research protocols · 2026Article
- Physical Activity and Education in the Care of IBD: The Role of the Physiotherapist-A Narrative Review.Journal of clinical medicine · 2025Review
- Sedentary Behavior as a Risk Factor for Liver Fibrosis Development in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Effects of Therapeutic Doses of α-Tocopherol and Ascorbic Acid on Metabolic Profile and Oxidant Balance Indicators on Day 21 of Experimental Hypokinesia.Bulletin of experimental biology and medicine · 2025Article
- Study design of 'PASIBO' - co-creation and development of a physical activity intervention to patients with inflammatory bowel disease.BMC health services research · 2025Article
- The Effects of Group Fitness Programs Zumba and MoFit on Body Composition Parameters in Women.Life (Basel, Switzerland) · 2025Article
- Physical Activity and Psychological Symptoms in University Teachers Improved Post-COVID-19 Lockdown, but Sedentary Behavior Persisted.Healthcare (Basel, Switzerland) · 2025Article
- Mechanisms of Post-stroke Stiff-Knee Gait: A Narrative Review.American journal of physical medicine & rehabilitation · 2025Review
- The impact of 60 days of -6° head down tilt bed rest on mitochondrial content, respiration and regulators of mitochondrial dynamics.The Journal of physiology · 2025Article
- Does Knowledge About Physical Activity Translate into More Active Populations?Healthcare (Basel, Switzerland) · 2025Article
- Microbial metabolism mediates the deteriorative effects of sedentary behaviour on insulin resistance.Clinical and translational medicine · 2025Article
- Impact of resistance and high-intensity interval training on body composition, physical function, and temporal dynamics of adaptation in older women with impaired cardiometabolic health: a randomized clinical trial.BMC sports science, medicine & rehabilitation · 2025Article
- Associations between takeaway food consumption, physical activity levels, and their joint effect with comorbid depression and anxiety symptoms among Chinese university students.BMC public health · 2025Article
- Associations between sedentary behaviour and sarcopenia among patients aged 40 and older with chronic obstructive pulmonary disease: a cross-sectional study.BMC public health · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Physical inactivity, i.e. not reaching the recommended level of physical activity (PA), and sedentary behaviours (SB), i.e. sitting time, have been associated with increased risk for common metabolic diseases. Recent epidemiological data suggest that high volumes of SB are detrimental to metabolic health, even in the presence of regular exercise, i.e. moderate/vigorous PA. This suggests that the health effects of SB are independent from those of exercise. However, experimentally testing this hypothesis is complicated because of the difficulty in disassociating SB from PA. Bedrest studies, a traditional space science model, can offer new insights. In some bedrest studies, an exercise training protocol has been used to counteract the harmful effects of inactivity. While bedrest induces an inactive and sedentary state, exercise with bedrest represents a unique model of sedentary yet physically active people. Here, we review bedrest studies with and without exercise training. Although exercise training prevents the loss of muscle mass and function, even large volumes of exercise are not sufficient to fully counteract the negative metabolic adaptations triggered by inactivity. This observation supports the existence of independent adverse health effects of SB, but also the potential benefits of non-exercise activity, i.e. daily living light PA. We gathered available data to examine the complex relationships between exercise, non-exercise activity, SB and health outcomes. Given the large amount of SB in modern societies, the sole promotion of exercise, i.e. moderate/vigorous PA may be insufficient, and promotion of light PA may be a complimentary approach to improve health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.