Evidence map›Paper›PMID 33501614›Full record

ReviewJournal of endocrinological investigation2021

The endocrine disruptor cadmium: a new player in the pathophysiology of metabolic diseases.

V M Bimonte, Z M Besharat, A Antonioni, V Cella, A Lenzi, E Ferretti, S Migliaccio

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. New Insight Into Male Infertility: Deviation From Basic Tenets of Life.Oxidative medicine and cellular longevity · 2026
    Review
  4. The effects of cadmium and high fructose diet on metabolic and reproductive health in female CD-1 mice.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Article
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  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

V M BimonteDepartment of Movement, Human and Health Sciences, Section of Health Sciences, Foro Italico University, Piazza Lauro De Bosis 6, 00195, Rome, Italy.
Z M BesharatDepartment of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Food Sciences, Sapienza University of Rome, Viiale Regina Elena 324, 00161, Rome, Italy.
A AntonioniDepartment of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Food Sciences, Sapienza University of Rome, Viiale Regina Elena 324, 00161, Rome, Italy.
V CellaDepartment of Movement, Human and Health Sciences, Section of Health Sciences, Foro Italico University, Piazza Lauro De Bosis 6, 00195, Rome, Italy.
A LenziDepartment of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Food Sciences, Sapienza University of Rome, Viiale Regina Elena 324, 00161, Rome, Italy.
E FerrettiDepartment of Experimental Medicine, Section of Medical Pathophysiology, Endocrinology and Food Sciences, Sapienza University of Rome, Viiale Regina Elena 324, 00161, Rome, Italy.
S MigliaccioDepartment of Movement, Human and Health Sciences, Section of Health Sciences, Foro Italico University, Piazza Lauro De Bosis 6, 00195, Rome, Italy. silvia.migliaccio@uniroma4.it.ORCID http://orcid.org/0000-0002-4563-6630
Sapienza University of Rome · ITForo Italico University of Rome · IT

Funding

MIUR, PRIN 2017HBHA98Regione Lazio (IT) 85-2017-15308
6 · The paper itself

Abstract

Cadmium (Cd), a highly toxic heavy metal, is found in soil, environment and contaminated water and food. Moreover, Cd is used in various industrial activities, such as electroplating, batteries production, fertilizers, while an important non-occupational source is represented by cigarette smoking, as Cd deposits in tobacco leaves. Since many years it is clear a strong correlation between Cd body accumulation and incidence of many diseases. Indeed, acute exposure to Cd can cause inflammation and affect many organs such as kidneys and liver. Furthermore, the attention has focused on its activity as environmental pollutant and endocrine disruptor able to interfere with metabolic and energy balance of living beings. Both in vitro and in vivo experiments have demonstrated that the Cd-exposure is related to metabolic diseases such as obesity, diabetes and osteoporosis even if human studies are still controversial. Recent data show that Cd-exposure is associated with atherosclerosis, hypertension and endothelial damage that are responsible for cardiovascular diseases. Due to the large environmental diffusion of Cd, in this review, we summarize the current knowledge concerning the role of Cd in the incidence of metabolic and cardiovascular diseases.

Indexed as

CadmiumEndocrine DisruptorsHumansMetabolic DiseasesCadmiumEndocrine DisruptorsBoneCadmiumEndocrine disruptorsMetabolic chronic diseasesObesity

Identifiers

PMID33501614
OpenAlexW3123783933

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.