Evidence map›Paper›PMID 33501440›Full record

ArticlebioRxiv : the preprint server for biology2021

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2.

Avi J Samelson, Quang Dinh Tran, Rémy Robinot, Lucia Carrau, Veronica V Rezelj, Alice Mac Kain, Merissa Chen, Gokul N Ramadoss, Xiaoyan Guo, Shion A Lim and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Avi J SamelsonInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Quang Dinh TranInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
Rémy RobinotInstitut Pasteur, CIVIC Group, Virus and Immunity Unit, CNRS UMR 3569, 75015 Paris, France.
Lucia CarrauDepartment of Microbiology, Icahn School of Medicine, New York, NY 10029.
Veronica V RezeljInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
Alice Mac KainInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
Merissa ChenInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Gokul N RamadossGladstone Institutes, San Francisco, 94158, CA, USA.
Xiaoyan GuoInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Shion A LimDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
Irene LuiDepartment of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, 94158, USA.
James NunezDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
Sarah J RockwoodGladstone Institutes, San Francisco, 94158, CA, USA.
Jianhui WangSchool of Medicine, Southern University of Science and Technology, Shenzhen, China 518055.
Na LiuSchool of Medicine, Southern University of Science and Technology, Shenzhen, China 518055.
Jared Carlson-StevermerSynthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
Jennifer OkiSynthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
Travis MauresSynthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
Kevin HoldenSynthego Corporation, Redwood City, CA 94063, USA, Department of Biology, Massachusetts Institute of Technology, Cambridge, 02142, USA.
Jonathan S WeissmanDepartment of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.
James A WellsChan-Zuckerberg Biohub, San Francisco, CA 94158, USA.
Bruce R ConklinGladstone Institutes, San Francisco, 94158, CA, USA.
Benjamin R TenOeverDepartment of Microbiology, Icahn School of Medicine, New York, NY 10029.
Lisa A ChakrabartiInstitut Pasteur, CIVIC Group, Virus and Immunity Unit, CNRS UMR 3569, 75015 Paris, France.
Marco VignuzziInstitut Pasteur, Viral Populations and Pathogenesis Unit, CNRS UMR 3569, 75015 Paris, France.
Ruilin TianInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
Martin KampmannInstitute for Neurodegenerative Diseases, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.
University of California, San Francisco · USCentre National de la Recherche Scientifique · FRSynthego (United States) · USGladstone Institutes · USHoward Hughes Medical Institute · USIcahn School of Medicine at Mount Sinai · USSouthern University of Science and Technology · CN

Funding

Mechanisms of tau misfolding in neurons elucidated by deep mutational scanning and CRISPR screeningF32AG063487 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAMELSON, AVI JACOB · 2019 to 2021
$195k
NIA NIH HHS F32 AG063487
6 · The paper itself

Abstract

SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells. We found that the protein BRD2 is required for

Identifiers

PMID33501440
PMCPMC7836110
OpenAlexW3123355212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.