ArticleBrain communications2021
Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Region- and time- specific effects of ketamine on cerebral blood flow: a randomized controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- Partially Different Mechanisms of Social and Nonsocial Attention: Evidence From Changes in Cueing Effects and Underlying Frontal Cortex Processing Over Time.Psychophysiology · 2026Article
- Distinct patterns of default mode network functional connectivity between adolescents with bipolar disorder and major depressive disorder.Frontiers in psychiatry · 2026Article
- Effect of Tai Chi combined with visual-action-sensory rehabilitation therapies on cognitive function in acute ischemic stroke: a study protocol for a randomized controlled trial.Annals of medicine · 2025Article
- The effects of age and delay task duration on attentional boost effect: evidence from behavior and fNIRS.BMC psychology · 2025Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.NeuroImage · 2025Article
- Sex-specific cerebrovascular reactivity differences in autistic children related to functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Structural Disconnections Caused by White Matter Hyperintensities in Post-Stroke Spatial Neglect.Human brain mapping · 2024Article
- Shared subcortical arousal systems across sensory modalities during transient modulation of attention.bioRxiv : the preprint server for biology · 2024Article
- Enhanced attention-related alertness following right anterior insular cortex neurofeedback training.iScience · 2024Article
- Meta-modeling the effects of anodal left prefrontal transcranial direct current stimulation on working memory performance.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Atlas for the Lateralized Visuospatial Attention Networks (ALANs): Insights from fMRI and network analyses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Elevated CRP and TNF-α levels are associated with blunted neural oscillations serving fluid intelligence.Brain, behavior, and immunity · 2023Article
- Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad.Brain : a journal of neurology · 2023Article
- Advances in the Rehabilitation of Hemispatial Inattention.Current neurology and neuroscience reports · 2023Review
- Obesity mechanism after hypothalamic damage: Cohort analysis of neuroimaging, psychological, cognitive, and clinical phenotyping data.Frontiers in endocrinology · 2023Article
- Directional and general impairments in initiating motor responses after stroke.Brain communications · 2023Article
- Musical Experience Relates to Insula-Based Functional Connectivity in Older Adults.Brain sciences · 2022Article
- Effects of Virtual Reality-Based Multimodal Audio-Tactile Cueing in Patients With Spatial Attention Deficits: Pilot Usability Study.JMIR serious games · 2022Article
- Resting State Functional Connectivity between Dorsal Attentional Network and Right Inferior Frontal Gyrus in Concussed and Control Adolescents.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The clinical link between spatial and non-spatial attentional aspects in patients with hemispatial neglect is well known; in particular, an increase in alerting can transitorily help to allocate attention towards the contralesional side. In models of attention, this phenomenon is postulated to rely on an interaction between ventral and dorsal cortical networks, subtending non-spatial and spatial attentional aspects, respectively. However, the exact neural underpinnings of the interaction between these two networks are still poorly understood. In the present study, we included 80 right-hemispheric patients with subacute stroke (50% women; age range: 24-96), 33 with and 47 without neglect, as assessed by paper-pencil cancellation tests. The patients performed a computerized task in which they were asked to respond as quickly as possible by button-press to central targets, which were either preceded or not preceded by non-spatial, auditory warning tones. Reaction times in the two different conditions were measured. In neglect patients, a warning tone, enhancing activity within the ventral attentional 'alerting' network, could boost the reaction (in terms of shorter reaction times) of the dorsal attentional network to a visual stimulus up to the level of patients without neglect. Critically, using voxel-based lesion-symptom mapping analyses, we show that this effect significantly depends on the integrity of the right anterior insula and adjacent inferior frontal gyrus, i.e., right-hemispheric patients with lesions involving these areas were significantly less likely to show shorter reaction times when a warning tone was presented prior to visual target appearance. We propose that the right anterior insula and inferior frontal gyrus are a critical hub through which the ventral attentional network can 'alert' and increase the efficiency of the activity of the dorsal attentional network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.