ArticleInternational journal of burns and trauma2020
Regeneration of mechanical sciatic nerve injury is affected by cold and heat exposure: involvements of the TRPM2 and TRPM8 channels.
Article in International journal of burns and trauma, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- Burn-Safe Biodegradable Magnetocaloric Composites for Temperature-Controlled Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Boric Acid Diminishes Sciatic Nerve Injury-Induced Apoptosis, Oxidative Stress, and Pain via The Block of TRPV1 Channel in Mice.Biological trace element research · 2026Article
- Effect of Hesperidin on Sciatic Nerve Damage in STZ-Induced Diabetic Neuropathy: Modulation of TRPM2 Channel.Neurotoxicity research · 2023Article
- TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMechanical sciatic nerve (MSN) injury has a high rate within trauma cases. Heat and cold exposure in the treatments of MSN injuries have been clinically used in human. The MSN injury results in apoptosis, overload Ca
objectiveThe protective roles of cold and heat treatments via modulation of TRPM2 and TRPM8 were evaluated on MSN injury-induced neurotoxicity in
methodThe mice sciatic nerves and SH-SY5Y cells were divided into control (37°C), cold (10°C), and moderate heat (40°C) groups.
resultsOur data identified a decrease in injury diameter in the neurons following heat exposure, but not cold exposure. In addition, the results of laser confocal microscopy analyses were indicative of a protective role of TRPM8 antagonist (ACA) against cold-induced increases in Ca
conclusionsThe heat treatment via possible modulation of TRPM2 channel and heat shock proteins induced protective actions against injury-mediated increases of oxidative stress, excitotoxicity, and apoptosis in the sciatic nerve and SH-SY5Y cells.
Indexed as
Identifiers
33500840PMC7811937W3123252303What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.