Evidence map›Paper›PMID 33500721›Full record

ReviewTheranostics2021

Cancer photo-immunotherapy: from bench to bedside.

Miao Wang, Jie Rao, Meng Wang, Xiaosong Li, Kaili Liu, Mark F Naylor, Robert E Nordquist, Wei R Chen, Feifan Zhou

Open access · goldAbstract readReview
In one paragraph

Review in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 87 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Phototherapy in cancer treatment: strategies and challenges.Signal transduction and targeted therapy · 2025
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Bioluminescent Systems for Theranostic Applications.International journal of molecular sciences · 2024
    Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Miao WangSchool of Biomedical Engineering, Hainan University, Haikou, 570228, China.
Jie RaoSchool of Biomedical Engineering, Hainan University, Haikou, 570228, China.
Meng WangCollege of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Xiaosong LiDepartment of Oncology, the First Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China.
Kaili LiuStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK 73019, USA.
Mark F NaylorBaylor Scott & White Healthcare, Waco, Texas 76712, USA.
Robert E NordquistImmunophotonics, Inc., 4320 Forest Park Ave., #303 (BAL), St. Louis, MO 63108, USA.
Wei R ChenStephenson School of Biomedical Engineering, The University of Oklahoma, Norman, OK 73019, USA.
Feifan ZhouSchool of Biomedical Engineering, Hainan University, Haikou, 570228, China.
Hainan University · CNUniversity of Oklahoma · USBaylor Scott & White Health · USFirst Affiliated Hospital of Chinese PLA General Hospital · CNNeoPhotonics (United States) · USShenzhen University · CN

Funding

Mechanistic study on synergistic photo-immunological effects of laser immunotherapy for metastatic cancersR01CA205348 · NCI · UNIVERSITY OF OKLAHOMA · PI CHEN, WEI R. · 2017 to 2021
$1.5M
NCI NIH HHS R01 CA205348
6 · The paper itself

Abstract

Targeted therapy and immunotherapy in combination is considered the ideal strategy for treating metastatic cancer, as it can eliminate the primary tumors and induce host immunity to control distant metastases. Phototherapy, a promising targeted therapy, eradicates primary tumors using an appropriate dosage of focal light irradiation, while initiating antitumor immune responses through induced immunogenic tumor cell death. Recently, phototherapy has been employed to improve the efficacy of immunotherapies such as chimeric antigen receptor T-cell therapy and immune checkpoint inhibitors. Phototherapy and immunoadjuvant therapy have been used in combination clinically, wherein the induced immunogenic cell death and enhanced antigen presentation synergy, inducing a systemic antitumor immune response to control residual tumor cells at the treatment site and distant metastases. This review summarizes studies on photo-immunotherapy, the combination of phototherapy and immunotherapy, especially focusing on the development and progress of this unique combination from a benchtop project to a promising clinical therapy for metastatic cancer.

Indexed as

AnimalsCombined Modality TherapyHumansImmunotherapyNeoplasmsPhototherapyCancercombination therapyimmunotherapyphoto-immunotherapyphototherapy

Identifiers

PMID33500721
PMCPMC7797676
OpenAlexW3113320794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.