Evidence map›Paper›PMID 33500719›Full record

ArticleTheranostics2021

Silencing PCBP2 normalizes desmoplastic stroma and improves the antitumor activity of chemotherapy in pancreatic cancer.

Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F Staveley-OCarroll, Guangfu Li, Kun Cheng

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
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  4. PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential.Journal of molecular medicine (Berlin, Germany) · 2025
    Review
  5. Article
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  14. Iron as spirit of life to share under monopoly.Journal of clinical biochemistry and nutrition · 2022
    Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Yuanke LiDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.
Zhen ZhaoDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.
Chien-Yu LinDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.
Yanli LiuDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.
Kevin F Staveley-OCarrollDepartment of Surgery, School of Medicine, University of Missouri, One Hospital Drive, Columbia, MO 65212.
Guangfu LiDepartment of Surgery, School of Medicine, University of Missouri, One Hospital Drive, Columbia, MO 65212.
Kun ChengDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, 2464 Charlotte Street, Kansas City, MO 64108, USA.
University of Missouri–Kansas City · US

Funding

Targeted delivery of PCBP2 siRNA for treating alcoholic liver fibrosisR01AA021510 · NIAAA · UNIVERSITY OF MISSOURI KANSAS CITY · PI CHENG, KUN · 2012 to 2022
$3.8M
Development of a targeted delivery platform for checkpoint inhibitorsR01CA231099 · NCI · UNIVERSITY OF MISSOURI KANSAS CITY · PI CHENG, KUN · 2018 to 2022
$1.8M
Peptide-based conjugate for a water-insoluble drug treating advanced prostate cancerR01GM121798 · NIGMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI CHENG, KUN · 2017 to 2020
$1.2M
NCI NIH HHS R01 CA231099NIAAA NIH HHS R01 AA021510NIGMS NIH HHS R01 GM121798
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsAntimetabolites, AntineoplasticCarcinoma, Pancreatic DuctalDeoxycytidineGemcitabineGene SilencingHumansMicePancreatic NeoplasmsPancreatic Stellate CellsRNA-Binding ProteinsRNA, Small InterferingStromal CellsTumor Cells, CulturedAntimetabolites, AntineoplasticDeoxycytidineGemcitabinePCBP2 protein, humanRNA-Binding ProteinsRNA, Small Interferingnanocomplexpancreatic cancerPCBP2siRNAtumor stroma

Identifiers

PMID33500719
PMCPMC7797682
OpenAlexW3110859630

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.