Evidence map›Paper›PMID 33500707›Full record

ArticleTheranostics2021

Transplantation of autologous extracellular vesicles for cancer-specific targeting.

Alessandro Villa, Mariangela Garofalo, Daniela Crescenti, Nicoletta Rizzi, Electra Brunialti, Andrea Vingiani, Paolo Belotti, Carlo Sposito, Silvia Franzè, Francesco Cilurzo and 11 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
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  20. Advances in Therapeutic Applications of Extracellular Vesicles.International journal of nanomedicine · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 2 institutions in 1 country.

Alessandro VillaDepartment of Health Sciences, University of Milan, Milan, Italy.
Mariangela GarofaloDepartment of Health Sciences, University of Milan, Milan, Italy.
Daniela CrescentiDepartment of Health Sciences, University of Milan, Milan, Italy.
Nicoletta RizziDepartment of Health Sciences, University of Milan, Milan, Italy.
Electra BrunialtiDepartment of Health Sciences, University of Milan, Milan, Italy.
Andrea VingianiDepartment of Oncology and Hemato-Oncology, University of Milan and Pathology and Laboratory Medicine, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.
Paolo BelottiDepartment of Oncology and Hemato-Oncology, University of Milan and HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.
Carlo SpositoDepartment of Oncology and Hemato-Oncology, University of Milan and HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.
Silvia FranzèDepartment of Pharmaceutical Sciences, University of Milan, Italy.
Francesco CilurzoDepartment of Pharmaceutical Sciences, University of Milan, Italy.
Giancarlo PruneriDepartment of Oncology and Hemato-Oncology, University of Milan and Pathology and Laboratory Medicine, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.
Camilla RecordatiDepartment of Veterinary Medicine, University of Milan, Milano, Italy.
Chiara GiudiceDepartment of Veterinary Medicine, University of Milan, Milano, Italy.
Alessia GiordanoDepartment of Veterinary Medicine, University of Milan, Milano, Italy.
Monica TortoretoMolecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Giangiacomo BerettaDepartment of Environmental Science and Policy, University of Milan, Milan, Italy.
Damiano StefanelloDepartment of Veterinary Medicine, University of Milan, Milano, Italy.
Giacomo ManentiAnimal Health and Welfare Unit, Department of Applied Research and Technical Development, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Nadia ZaffaroniMolecular Pharmacology Unit, Department of Applied Research and Technological Development, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Vincenzo MazzaferroDepartment of Oncology and Hemato-Oncology, University of Milan and HPB Surgery and Liver Transplantation, Istituto Nazionale Tumori IRCCS Foundation (INT), Milan, Italy.
Paolo CianaDepartment of Health Sciences, University of Milan, Milan, Italy.
University of Milan · ITFondazione IRCCS Istituto Nazionale dei Tumori · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nano- and microsized extracellular vesicles (EVs) are naturally occurring cargo-bearing packages of regulatory macromolecules, and recent studies are increasingly showing that EVs are responsible for physiological intercellular communication. Nanoparticles encapsulating anti-tumor theranostics represent an attractive "exosome-interfering" strategy for cancer therapy.

Indexed as

AnimalsApoptosisBreast NeoplasmsCase-Control StudiesCell ProliferationColorectal NeoplasmsDogsExtracellular VesiclesFemaleHumansLiver NeoplasmsMaleMiceMice, Inbred C57BLMice, SCIDTissue Distributionbiocompatible nanoparticlescancer imagingdrug deliveryfluorescencetheranostic agents

Identifiers

PMID33500707
PMCPMC7797692
OpenAlexW3111331165

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.