Evidence map›Paper›PMID 33500558›Full record

ReviewNature reviews. Genetics2021

Parental nucleosome segregation and the inheritance of cellular identity.

Thelma M Escobar, Alejandra Loyola, Danny Reinberg

Open access · greenAbstract readReview
In one paragraph

Review in Nature reviews. Genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 112 citations in OpenAlex.

  1. Article
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  9. PRMT5 activity sustains histone production to maintain genome integrity.bioRxiv : the preprint server for biology · 2025
    Article
  10. Review
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  18. POLD3 as Controller of Replicative DNA Repair.International journal of molecular sciences · 2024
    Review
  19. Article
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Thelma M Escobar *Howard Hughes Medical Institute, Chevy Chase, MD, USA.ORCID 0000-0001-5352-3903
Alejandra Loyola *Fundación Ciencia & Vida, Santiago, Chile.ORCID 0000-0002-4643-9436
Danny ReinbergHoward Hughes Medical Institute, Chevy Chase, MD, USA. danny.reinberg@nyulangone.org.ORCID 0000-0003-4288-2016
Howard Hughes Medical Institute · USSan Sebastián University · CL

Funding

Repression via Facultative HeterochromatinR01CA199652 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI REINBERG, DANNY · 2015 to 2025
$4.2M
Howard Hughes Medical InstituteNCI NIH HHS R01 CA199652
6 · The paper itself

Abstract

Gene expression programmes conferring cellular identity are achieved through the organization of chromatin structures that either facilitate or impede transcription. Among the key determinants of chromatin organization are the histone modifications that correlate with a given transcriptional status and chromatin state. Until recently, the details for the segregation of nucleosomes on DNA replication and their implications in re-establishing heritable chromatin domains remained unclear. Here, we review recent findings detailing the local segregation of parental nucleosomes and highlight important advances as to how histone methyltransferases associated with the establishment of repressive chromatin domains facilitate epigenetic inheritance.

Indexed as

Cell LineageChromatin Assembly and DisassemblyDNA ReplicationEpigenesis, GeneticInheritance PatternsHumansNucleosomesParentsNucleosomes

Identifiers

PMID33500558
PMCPMC8609916
OpenAlexW3125252263

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.