Evidence map›Paper›PMID 33500545›Full record

ArticleCommunications biology2021

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer.

Domenico Albino, Martina Falcione, Valeria Uboldi, Dada Oluwaseyi Temilola, Giada Sandrini, Jessica Merulla, Gianluca Civenni, Aleksandra Kokanovic, Alessandra Stürchler, Dheeraj Shinde and 15 more

Abstract read
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Pooled it
  4. Review
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  8. Review
  9. Extracellular vesicle-mediated chemoresistance in breast cancer: focus on miRNA cargo.Extracellular vesicles and circulating nucleic acids · 2025
    Review
  10. Article
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  13. Article
  14. Article
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  16. Extracellular vesicles as tools and targets in therapy for diseases.Signal transduction and targeted therapy · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Domenico AlbinoInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Martina FalcioneInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Valeria UboldiInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Dada Oluwaseyi TemilolaInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa and Integrative Biomedical Sciences Division, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-8470-0666
Giada SandriniInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.ORCID 0000-0002-7294-3863
Jessica MerullaInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Gianluca CivenniInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Aleksandra KokanovicInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Alessandra StürchlerInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Dheeraj ShindeInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.ORCID 0000-0002-5113-3167
Mariangela GarofaloDepartment of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy.
Ricardo Pereira MestreMedical Oncology, Oncology Institute of Southern Switzerland, 6500, Bellinzona, Switzerland.ORCID 0000-0002-3123-3697
Vera ConstâncioCancer Biology and Epigenetics Group, Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.
Martha WiumInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa and Integrative Biomedical Sciences Division, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0527-1750
Jacopo BurrelloLaboratory for Cardiovascular Theranostics, Cardiocentro Ticino Foundation, USI, Lugano, Switzerland.ORCID 0000-0001-7884-7314
Nicolò BaranziniDepartment of Biotechnology and Life Science, Università degli Studi dell'Insubria, Varese, Italy.
Annalisa GrimaldiDepartment of Biotechnology and Life Science, Università degli Studi dell'Insubria, Varese, Italy.
Jean-Philippe TheurillatInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Daniela BossiInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.
Lucio BarileLaboratory for Cardiovascular Theranostics, Cardiocentro Ticino Foundation, USI, Lugano, Switzerland.ORCID 0000-0002-5827-0439
Rui M HenriqueCancer Biology and Epigenetics Group, Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.
Carmen JeronimoCancer Biology and Epigenetics Group, Research Center (CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto), Porto, Portugal.ORCID 0000-0003-4186-5345
Luiz Fernando ZerbiniInternational Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town, South Africa and Integrative Biomedical Sciences Division, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0736-9508
Carlo V CatapanoInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland.ORCID 0000-0002-7079-557X
Giuseppina M CarboneInstitute of Oncology Research (IOR), Università della Svizzera Italiana (USI), 6500, Bellinzona, Switzerland. pina.carbone@ior.usi.ch.ORCID 0000-0003-4652-585X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (EVs) are relevant means for transferring signals across cells and facilitate propagation of oncogenic stimuli promoting disease evolution and metastatic spread in cancer patients. Here, we investigated the release of miR-424 in circulating small EVs or exosomes from prostate cancer patients and assessed the functional implications in multiple experimental models. We found higher frequency of circulating miR-424 positive EVs in patients with metastatic prostate cancer compared to patients with primary tumors and BPH. Release of miR-424 in small EVs was enhanced in cell lines (LNCaP

Indexed as

Prostatic NeoplasmsAnimalsCell-Derived MicroparticlesCell Line, TumorCell Transformation, NeoplasticExtracellular VesiclesHumansMaleMiceMice, Inbred NODMice, SCIDMice, TransgenicMicroRNAsModels, TheoreticalNeoplasm InvasivenessMicroRNAsMIRN424 microrna, human

Identifiers

PMID33500545
PMCPMC7838273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.