ArticleScientific reports2021
Inflammation predicts new onset of depression in men, but not in women within a prospective, representative community cohort.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Peripheral Inflammation and Sleep Loss Induce Coordinated Motivational Changes: An Experimental Two-Hit Stress Model.Journal of sleep research · 2026Article
- Associations between inflammation markers (CRP and IL-6) and depression among adolescents and young adults in Soweto and Durban, South Africa.Brain, behavior, & immunity - health · 2026Article
- Association Between Circulating Cytokines and Psychosomatic Syndromes in Patients with Mood Disorders.Clinical neuropsychiatry · 2025Article
- Does Mental Distress Predict Cardiac Surgical Outcome?The Thoracic and cardiovascular surgeon · 2025Article
- Associations between IL-6 and trajectories of depressive symptoms across the life course: Evidence from ALSPAC and UK Biobank cohorts.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Revealing the Causal Relationship Between Differential White Blood Cell Counts and Depression: A Bidirectional Two-Sample Mendelian Randomization Study.Depression and anxiety · 2025Article
- Pre-Surgery Inflammatory and Angiogenesis Biomarkers as Predictors of 12-Month Cancer-Related Distress: Results from the ColoCare Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study.Translational psychiatry · 2023Article
- Screening for loneliness in representative population samples: Validation of a single-item measure.PloS one · 2023Article
- Self-esteem only goes so far: the moderating effect of social media screen time on self-esteem and depressive symptoms.Behaviour & information technology · 2023Article
- Prescription Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) and Incidence of Depression Among Older Cancer Survivors With Osteoarthritis: A Machine Learning Analysis.Cancer informatics · 2023Article
- Role of Inflammation in Traumatic Brain Injury-Associated Risk for Neuropsychiatric Disorders: State of the Evidence and Where Do We Go From Here.Biological psychiatry · 2022Review
- The Antidepressant Duloxetine Inhibits Platelet Function and Protects against Thrombosis.International journal of molecular sciences · 2022Article
- Understanding Vulnerability to Late-Life Suicide.Current psychiatry reports · 2021Review
- Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.International journal of molecular sciences · 2021Article
- Characterizing Sex Differences in Depressive-Like Behavior and Glial Brain Cell Changes Following Peripheral Nerve Injury in Mice.Frontiers in behavioral neuroscience · 2021Article
- Neuroinflammation as a pathophysiological factor in the development and maintenance of functional seizures: A hypothesis.Epilepsy & behavior reports · 2021Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression has been associated with increased inflammation. However, only few large-scale, prospective studies have evaluated whether inflammation leads to new cases of depression and whether this association can be found in men and women. Longitudinal data of N = 10,357 adult participants with no evidence of depression at baseline (based on Patient Health Questionnaire (PHQ-9), lifetime diagnoses, and current antidepressant medication) were evaluated for depression 5 years later. Multivariate logistic regression models were used to predict the onset of depression based on C-reactive protein (CRP) and white blood cell count (WBC). We used interaction terms and separate analyses in men and women to investigate gender-dependent associations. Based on both markers, inflammation was predictive of new cases of depression 5 years later, even when adjusting for sociodemographic, physical health, health behavior variables, and baseline depression symptoms. As established by interaction terms and separate analyses, inflammatory markers were predictive of depression in men, but not in women. Additional predictors of new onset of depression were younger age, loneliness, smoking (only in men), cancer and less alcohol consumption (only in women). The study indicates gender differences in the etiology of depressive disorders within the community, with a greater role of physical factors in men.
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