ArticleNature communications2021
Role of mutational reversions and fitness restoration in Zika virus spread to the Americas.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The residue 86 of the Getah virus E2 glycoprotein mediates both glycosaminoglycan- and LDLR-dependent infection.PLoS pathogens · 2026Article
- Breaking barriers and beyond: Mechanisms and pathological implications of Zika virus traversal across blood-tissue interfaces.Virologica Sinica · 2026Review
- Safeguarding future generations: a One Health perspective on children, climate change, and infectious threats.Frontiers in public health · 2026Review
- Zika Virus: A Tale of Two Lineages.Pathogens (Basel, Switzerland) · 2025Review
- Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus.Nature communications · 2025Article
- Genomic characterization of arboviruses discovered between the 1950s and 1980s.Journal of virology · 2025Article
- Vectors on the Move: How Climate Change Fuels the Spread of Arboviruses in Europe.Microorganisms · 2025Review
- ZIKA Virus, an Emerging Arbovirus in India: A Glimpse of Global Genetic Lineages.Microorganisms · 2025Review
- First Evidence of Spillover ofTransboundary and emerging diseases · 2025Article
- Is the Zika virus re-emerging as a distinct genetic lineage in India?Access microbiology · 2025Article
- An accumulated mutation gained in mosquito cells enhances Zika virus virulence and fitness in mice.Journal of virology · 2024Article
- Preexisting inter-serotype immunity drives antigenic evolution of dengue virus serotype 2.Virology · 2024Article
- Mutations in SARS-CoV-2 variant nsp6 enhance type-I interferon antagonism.Emerging microbes & infections · 2023Article
- Cross-neutralization and viral fitness of SARS-CoV-2 Omicron sublineages.Emerging microbes & infections · 2023Article
- Zoonotic mosquito-borne arboviruses: Spillover, spillback, and realistic mitigation strategies.Science translational medicine · 2023Review
- An in vitro workflow to create and modify infectious clones using replication cycle reaction.Virology · 2023Article
- Article
- Viral Protein Accumulation of Zika Virus Variants Links with Regulation of Innate Immunity for Differential Control of Viral Replication, Spread, and Response to Interferon.Journal of virology · 2023Article
- Mouse models of Zika virus transplacental transmission.Antiviral research · 2023Review
- Replication in the presence of dengue convalescent serum impacts Zika virus neutralization sensitivity and fitness.Frontiers in cellular and infection microbiology · 2023Article
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Authors and funding
13 authors.
Funding
Abstract
Zika virus (ZIKV) emerged from obscurity in 2013 to spread from Asia to the South Pacific and the Americas, where millions of people were infected, accompanied by severe disease including microcephaly following congenital infections. Phylogenetic studies have shown that ZIKV evolved in Africa and later spread to Asia, and that the Asian lineage is responsible for the recent epidemics in the South Pacific and Americas. However, the reasons for the sudden emergence of ZIKV remain enigmatic. Here we report evolutionary analyses that revealed four mutations, which occurred just before ZIKV introduction to the Americas, represent direct reversions of previous mutations that accompanied earlier spread from Africa to Asia and early circulation there. Our experimental infections of Aedes aegypti mosquitoes, human cells, and mice using ZIKV strains with and without these mutations demonstrate that the original mutations reduced fitness for urban, human-amplifed transmission, while the reversions restored fitness, increasing epidemic risk. These findings include characterization of three transmission-adaptive ZIKV mutations, and demonstration that these and one identified previously restored fitness for epidemic transmission soon before introduction into the Americas. The initial mutations may have followed founder effects and/or drift when the virus was introduced decades ago into Asia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.