Evidence map›Paper›PMID 33500344›Full record

ArticlemBio2021

Sphingomyelin Biosynthesis Is Essential for Phagocytic Signaling during Mycobacterium tuberculosis Host Cell Entry.

Patrick Niekamp, Gaelen Guzman, Hans C Leier, Ali Rashidfarrokhi, Veronica Richina, Fabian Pott, Caroline Barisch, Joost C M Holthuis, Fikadu G Tafesse

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 citations in OpenAlex.

  1. A critical signaling role for diacylglycerol in phagocytosis ofbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025
    Review
  6. Sphingosine kills Mycobacteria and suppresses mycobacterial lung infections.Journal of molecular medicine (Berlin, Germany) · 2025
    Article
  7. Article
  8. Olink proteomics and lipidomics analysis of serum from patients infected with non-tuberculous mycobacteria and Mycobacterium tuberculosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Article
  9. Article
  10. Article
  11. ThemBio · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. The role ofFrontiers in microbiology · 2024
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Patrick Niekamp *Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Gaelen Guzman *Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0002-7696-6034
Hans C LeierDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Ali RashidfarrokhiDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Veronica RichinaDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.
Fabian PottDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA.ORCID 0000-0003-3700-1691
Caroline BarischMolecular Infection Biology Division, Department of Biology and Chemistry, University of Osnabrück, Osnabrück, Germany.ORCID 0000-0002-1493-9006
Joost C M HolthuisMolecular Cell Biology Division, Department of Biology and Chemistry, University of Osnabrück, Osnabrück, Germany holthuis@uos.de tafesse@ohsu.edu.ORCID 0000-0001-8912-1586
Fikadu G TafesseDepartment of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, Oregon, USA holthuis@uos.de tafesse@ohsu.edu.ORCID 0000-0002-8575-4164
Oregon Health & Science University · USOsnabrück University · DE

Funding

Determining the role of sphingolipids in Mycobacterium tuberculosis infectionR01AI141549 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAFESSE, FIKADU G. · 2020 to 2025
$2.4M
Defining the role of host lipid repertoire in Mycobacterium tuberculosis infectionR21AI124225 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI TAFESSE, FIKADU G. · 2017 to 2018
$424k
NIAID NIH HHS R01 AI141549NIAID NIH HHS R21 AI124225
6 · The paper itself

Abstract

Phagocytosis by alveolar macrophages is the obligate first step in

Indexed as

Host-Pathogen InteractionsAnimalsBiosynthetic PathwaysCells, CulturedHumansMacrophages, AlveolarMiceMycobacterium tuberculosisPhagocytosisRAW 264.7 CellsSignal TransductionSphingomyelinsTHP-1 CellsSphingomyelinscell signalingMycobacterium tuberculosisphagocytosissphingolipidssphingomyelin

Identifiers

PMID33500344
PMCPMC7858061
OpenAlexW2958782225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.