Evidence map›Paper›PMID 33500339›Full record

ArticlemBio2021

Toxoplasma gondii Extends the Life Span of Infected Human Neutrophils by Inducing Cytosolic PCNA and Blocking Activation of Apoptotic Caspases.

Tatiane S Lima, Sharmila Mallya, Allen Jankeel, Ilhem Messaoudi, Melissa B Lodoen

Open access · goldAbstract read
In one paragraph

Article in mBio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Imaging mass cytometry of the immune microenvironment in alveolar echinococcosis.Frontiers in cellular and infection microbiology · 2026
    Article
  3. Bioactive materials · 2025
    Article
  4. mBio · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Toxoplasma keeps neutrophils alive.Nature reviews. Microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Tatiane S LimaDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Sharmila MallyaDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Allen JankeelDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Ilhem MessaoudiDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA.
Melissa B LodoenDepartment of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA mlodoen@uci.edu.ORCID 0000-0002-3366-6840
University of California, Irvine · US

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Dysregulation of maternal immunity during pregnancy by pregravid obesityR01AI145910 · NIAID · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM · 2019 to 2024
$3.4M
Maternal obesity and neonatal innate immunityR01AI142841 · NIAID · UNIVERSITY OF KENTUCKY · PI MESSAOUDI, ILHEM, VARLAMOV, OLEG · 2018 to 2024
$2.7M
Parasite dissemination in Toxoplasmic encephalitisR01AI120846 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LODOEN, MELISSA BRUCKNER · 2016 to 2020
$2.0M
Parasite dissemination in Toxoplasmic encephalitisR56AI120846 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LODOEN, MELISSA BRUCKNER · 2015 to 2015
$386k
Mechanisms of Toxoplasma gondii dissemination and transmigrationR56AI109074 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI LODOEN, MELISSA BRUCKNER · 2014 to 2014
$369k
NCATS NIH HHS UL1 TR001414NIAID NIH HHS R01 AI120846NIAID NIH HHS R01 AI142841NIAID NIH HHS R01 AI145910NIAID NIH HHS R56 AI109074NIAID NIH HHS R56 AI120846
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ApoptosisCaspase 3Caspase 8CaspasesCells, CulturedCell SurvivalCytosolGene Expression ProfilingHumansNeutrophilsProliferating Cell Nuclear AntigenSequence Analysis, RNAToxoplasmaUp-RegulationCASP8 protein, humanCaspase 3Caspase 8CaspasesPCNA protein, humanProliferating Cell Nuclear Antigenapoptosiscaspasehost-parasite interactionimmune evasionimmunityneutrophilparasitepathogenesisToxoplasma gondii

Identifiers

PMID33500339
PMCPMC7858050
OpenAlexW3125041542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.