ArticleCancer discovery2021
Chemotherapy Induces Senescence-Like Resilient Cells Capable of Initiating AML Recurrence.
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Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers.
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162citing papers in PubMed
24.9field-weighted citation impact, top 1% of its field
What it found
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Who cites it
162 citing papers in PubMed, 246 citations in OpenAlex.
- Therapy induced senescence promotes immunogenicity in acute myeloid Leukemia through reduced EZH2 activity.Nature communications · 2026Article
- The spatial and multi-omic landscape of Down syndrome leukemogenesis: moving beyond cellular heterogeneity.Experimental hematology & oncology · 2026Article
- Tumor cells escape from therapy-induced senescence: from molecular mechanisms to targeted intervention.Biology direct · 2026Review
- Oncogene inactivation-induced senescence facilitates tumor relapse.Nature communications · 2026Article
- Putting mammalian early embryonic cells into dormancy.Nature protocols · 2026Review
- Rapid Transcription Dynamics Confers Cytarabine Resistance in Acute Myeloid Leukemia.Blood cancer discovery · 2026Article
- Spatiotemporal organisation of residual disease in mouse and human BRCA1-deficient mammary tumours and breast cancer.Nature communications · 2026Article
- Prognostic significance of therapy-induced senescence and SASP dynamics in acute myeloid leukemia: a retrospective cohort study.BMC cancer · 2026Article
- Mitochondrial superoxide sustains a senescence-like phenotype in PARP- inhibited ovarian cancer cells by stabilizing HIF1α.Redox biology · 2026Article
- Diving into the transcriptional landscape of leukemic stem cells in acute myeloid leukemia at single-cell resolution.Journal of cancer research and clinical oncology · 2026Review
- Ferrous Iron Accumulation Is a Hallmark and Therapeutic Vulnerability of Therapy-Induced Senescence.bioRxiv : the preprint server for biology · 2026Article
- Dynamic, anthracycline-induced chromatin alterations enable ALDH1 expression as a mechanism of inducible leukemia resistance development.Blood research · 2026Article
- Exploiting cellular senescence in hematologic malignancies.Translational oncology · 2026Review
- Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide.Aging cell · 2026Article
- Disproportionality Analysis of Hematologic Adverse Event Signals Associated with Venetoclax in Combination with Senescence-Inducing Chemotherapy.Journal of clinical medicine · 2026Article
- Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Synthetic lethality of MCL-1 inhibition and CAR-T therapy in aggressive B-cell lymphoma.Leukemia · 2026Article
- Tumor-derived circulating DNA can induce senescence and SASP activation in mouse embryonic fibroblasts.Biogerontology · 2026Article
- Succinate receptor 1 restricts hematopoiesis and prevents acute myeloid leukemia progression.Nature communications · 2026Article
- The LMO2-LDB1-TAL1 complex regulates transcription networks in acute myeloid leukemia.Blood neoplasia · 2026Article
102 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 3 countries.
Cihangir DuyCancer Signaling and Epigenetics Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania. amm2014@med.cornell.edu cihangir.duy@fccc.edu.
Meng LiDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York.
Matt TeaterDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York.ORCID 0000-0001-9415-1659
Cem MeydanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.ORCID 0000-0002-0663-6216
Francine E Garrett-BakelmanDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York.ORCID 0000-0002-4771-628X
Tak C LeeDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York.
Christopher R ChinDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.ORCID 0000-0002-2140-3197
Ceyda DurmazDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.
Kimihito C KawabataDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York.
Eugen DhimoleaDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Constantine S MitsiadesDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Hartmut DoehnerUniversitätsklinikum Ulm, Ulm, Germany.
Richard J D'AndreaUniversity of South Australia, Adelaide, Australia.
Michael W BeckerUniversity of Rochester Medical Center, Rochester, New York.
Elisabeth M PaiettaOncology, Montefiore Medical Center, Bronx, New York.
Christopher E MasonDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, New York.ORCID 0000-0002-1850-1642
Martin CarrollUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Ari M MelnickDepartment of Medicine, Division of Hematology and Oncology, Weill Cornell Medicine, New York, New York. amm2014@med.cornell.edu cihangir.duy@fccc.edu.ORCID 0000-0002-8074-2287
Cornell University · USBroad Institute · USFox Chase Cancer Center · USMontefiore Medical Center · USUniversität Ulm · DEUniversity of Pennsylvania · USUniversity of Rochester Medical Center · USUniversity of South Australia · AU
Funding
Project-006U10CA180820 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI Peter J ODwyer · 2014 to 2026
$167.6MECOG-ACRIN Biospecimen Bank to Support NCTNU24CA196172 · NCI · ECOG-ACRIN MEDICAL RESEARCH FOUNDATION · PI STANLEY R. HAMILTON, Scott D Jewell · 2015 to 2026
$41.1MTargeting Epigenetic Circuits in B-Cell LymphomasR35CA220499 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI MELNICK, ARI M. · 2018 to 2024
$7.2MECOG-ACRIN Integrated Leukemia Translational Science Center (LTSC)UG1CA233332 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAI, SHENG, LEVINE, ROSS L · 2019 to 2025
$6.2MRole of Cytokines in Myeloma PathogenesisR01CA050947 · NCI · DANA-FARBER CANCER INSTITUTE · PI ANDERSON, KENNETH C., MITSIADES, CONSTANTINE S. · 1991 to 2018
$5.1MUnderstanding and Targeting Chemotherapy Resistance in Acute Myeloid LeukemiaR01CA198089 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CARROLL, MARTIN · 2015 to 2019
$3.3MAnalysis of E-selectin Ligands of Human Acute Leukemia Cells and their Biology in LeukemogenesisU01CA225730 · NCI · FLORIDA INTERNATIONAL UNIVERSITY · PI MITSIADES, CONSTANTINE S., SACKSTEIN, ROBERT · 2019 to 2023
$3.0MECOG-ACRIN INTEGRATED LEUKEMIA TRANSLATIONAL RESEARCH CENTERU10CA180827 · NCI · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI LEVINE, ROSS L, MELNICK, ARI M. · 2014 to 2018
$3.0MHumanized bone marrow-like model to study patient-derived myeloma xenograftsR01CA196664 · NCI · DANA-FARBER CANCER INST · PI GROEN, RICHARD, MITSIADES, CONSTANTINE S. · 2016 to 2018
$1.6MGenetic and epigenetic basis of relapse in acute myeloid leukemiaK08CA169055 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GARRETT-BAKELMAN, FRANCINE EVALINA · 2012 to 2016
$742kNCI NIH HHS K08 CA169055NCI NIH HHS R01 CA050947NCI NIH HHS R01 CA196664NCI NIH HHS R01 CA198089NCI NIH HHS R35 CA220499NCI NIH HHS U01 CA225730NCI NIH HHS U10 CA180820NCI NIH HHS U10 CA180827NCI NIH HHS U24 CA196172NCI NIH HHS UG1 CA233332
Abstract
Patients with acute myeloid leukemia (AML) frequently relapse after chemotherapy, yet the mechanism by which AML reemerges is not fully understood. Herein, we show that primary AML cells enter a senescence-like phenotype following chemotherapy
Indexed as
Remission InductionAnimalsCell Line, TumorHumansLeukemia, Myeloid, AcuteMiceMice, Inbred NODNeoplasm Recurrence, LocalNeoplastic Stem CellsPhenotype
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