Evidence map›Paper›PMID 33499889›Full record

Trial reportHealth and quality of life outcomes2021

Gender difference in the association between cough severity and quality of life among patients with postinfectious cough.

Wei Liu, Qinqin Wu, Bing Mao, Hongli Jiang

Open access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Health and quality of life outcomes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wei LiuPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, No.37 Guoxue Street, Chengdu, 610041, China.
Qinqin WuHealth Management Center, West China Hospital, Sichuan University, No.37 Guoxue Street, Chengdu, 610041, China.
Bing MaoPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, No.37 Guoxue Street, Chengdu, 610041, China.
Hongli JiangPneumology Group, Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, No.37 Guoxue Street, Chengdu, 610041, China. doc_jhl@163.com.ORCID http://orcid.org/0000-0003-4448-5508
Sichuan University · CN

Funding

National Natural Science Foundation of China 2018M643505National Natural Science Foundation of China 81700024National Natural Science Foundation of China 81900039Post-Doctor Research Project, West China Hospital, Sichuan University 2018HXBH039
6 · The paper itself

Abstract

backgroundDespite close link exists between cough severity and quality of life (QoL), whether gender difference is implied in the effect of cough on QoL has not been studied yet. This study primarily aims to investigate whether the association between cough severity and QoL is modified by gender in patients with postinfectious cough.

methodsSecondary analyses were performed in 180 participants with postinfectious cough in a multisite randomized controlled trial. Baseline demographics, clinical characteristics and score of cough specific quality of life questionnaire (CQLQ) were collected. Linear regression analyses were conducted to examine gender difference in CQLQ score and the association between cough severity and CQLQ score.

resultsDifference between women and men was not significant in CQLQ total score in the unadjusted analysis (P = 0.077). Women had a 2.20-point higher CQLQ total score than men (95% confidence interval (CI) 0.11-4.30; P = 0.039), after adjusting for age, cough duration, cough severity, and clinical center. Gender significantly modified the association between cough severity and CQLQ total score (coefficient 1.80, 95% CI 0.29-3.30; P = 0.020), after adjusting for age, cough duration, and study center. An increase of 1-point in cough severity was associated with a 2.55-point (95% CI 1.16-3.95) increase in CQLQ total score in women versus a 1.26-point (95% CI 0.20-2.31) increase in men (P = 0.020).

conclusionsFemale sex may be associated with worse QoL than men, and women's QoL may be more significantly impaired as cough symptom deteriorates. Gender difference should be taken into account in the clinical settings and research of cough and cough related QoL.

trial registrationChinese Clinical Trial Registry, ChiCTRTRC12002297. Registered 19 June 2012, http://www.chictr.org.cn/abouten.aspx .

Indexed as

Quality of LifeAdultChinaCommunicable DiseasesCoughFemaleHumansMaleMiddle AgedSeverity of Illness IndexSex FactorsSurveys and QuestionnairesCough severityCough specific quality of lifeGender differencePostinfectious cough

Identifiers

PMID33499889
PMCPMC7836494
OpenAlexW3124195154

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.