Evidence map›Paper›PMID 33499851›Full record

ArticleBMC medical genomics2021

Association of PICK1 and BDNF variations with increased risk of methamphetamine dependence among Iranian population: a case-control study.

Amir Tajbakhsh, Maliheh Alimardani, Mahla Asghari, Soheila Abedini, Sohrab Saghafi Khadem, Abolfazl Nesaei Bajestani, Forough Alipoor, Maryam Alidoust, Amir Savardashtaki, Peyman Hashemian and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 7 citations in OpenAlex.

  1. Protein interacting with C-kinase 1 (PICK1) regulates synaptic function and reversal learning in a mouse model for schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Amir TajbakhshPharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Maliheh AlimardaniDepartment of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mahla Asghari *Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Soheila Abedini *Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Sohrab Saghafi Khadem *Ibn-E-Sina and Dr Hejazi Psychiatry Hospital, University of Medical Sciences, Mashhad, Iran.
Abolfazl Nesaei BajestaniDepartment of Medical Genetics, Ayatollah Madani Hospital, Gonabad University of Medical Sciences, Gonabad, Iran.
Forough AlipoorIslamic Azad University Torbat-e Jam Branch, Torbat-e-Jam, Iran.
Maryam AlidoustDepartment of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Amir SavardashtakiEpilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Peyman HashemianMedical Genetics Research Centre, Mashhad University of Medical Sciences, Mashhad, Iran. HashemianP@mums.ac.ir.
Alireza PasdarDepartment of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. PasdarA@mums.ac.ir.ORCID 0000-0002-7864-9729
Mashhad University of Medical Sciences · IRGonabad University of Medical Sciences · IRIslamic Azad University, Tehran · IRShiraz University of Medical Sciences · IR

Funding

Mashhad University of Medical Sciences 931681
6 · The paper itself

Abstract

backgroundGenetic factors play an important role in susceptibility to methamphetamine dependency. In this line, protein that interact with C-kinase-1 (PICK1) and brain-derived neurotrophic factor (BDNF) genes are linked to methamphetamine dependence (substance use disorder). Thus, in a case-control study, we investigated the association between polymorphisms of PICK1 and BDNF genes and methamphetamine dependence in an Iranian population.

methodsTotal of 235 cases and 204 controls were recruited in a period between 2015 to 2018. The PICK1-rs713729, -rs2076369 and BDNF-rs6265 genotypes were determined via ARMS-PCR assay. Statistical analysis was performed, using SPSS 20.0, PHASE 2.1.1 program as well as SNP Analyzer 2.0.

resultsIn the present study, two polymorphisms including PICK1-rs713729 (OR 1.38 (CI 1.08-1.52; P-

conclusionOur findings indicate that the PICK1 gene polymorphism might affect the risk of methamphetamine dependency in our population.

Indexed as

Amphetamine-Related DisordersBrain-Derived Neurotrophic FactorGenetic Predisposition to DiseaseMethamphetamineNuclear ProteinsPolymorphism, Single NucleotideAdultCarrier ProteinsCase-Control StudiesFemaleHaplotypesHumansIranMaleMiddle AgedBDNF protein, humanBrain-Derived Neurotrophic FactorCarrier ProteinsMethamphetamineNuclear ProteinsPICk1 protein, humanAddictionAnd polymorphismsDopamine pathwayDrug abuseGlutamate pathwaySubstance dependenceSubstance use disorder (SUD)Variations

Identifiers

PMID33499851
PMCPMC7836203
OpenAlexW3114190399

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.