ArticleEnvironmental science & technology2021
Predicting Mixture Effects over Time with Toxicokinetic-Toxicodynamic Models (GUTS): Assumptions, Experimental Testing, and Predictive Power.
Article in Environmental science & technology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 40 citations in OpenAlex.
- Combined effects of a pyrethroid insecticide and azole fungicide on lepidopteran growth analysed with DEB-TKTD modelling.Ecotoxicology (London, England) · 2025Article
- A Bayesian neural ordinary differential equations framework to study the effects of chemical mixtures on survival.PLoS computational biology · 2025Article
- Combined Modeling of Multiple Exposure Routes for Terrestrial Arthropods Using the Toxicokinetic-Toxicodynamic BufferGUTS Model.Environmental science & technology · 2025Article
- MIXCOP-Implementation of a model to assess the time-dependent effects of mixed pesticides on a collembolan population.MethodsX · 2025Article
- From water to land-Usage of Generalized Unified Threshold models of Survival (GUTS) in an above-ground terrestrial context exemplified by honeybee survival data.Environmental toxicology and chemistry · 2025Article
- Evaluation of interspecies correlation estimation models to increase taxonomic diversity while reducing reliance on animal testing for chemicals evaluated under the Toxic Substances Control Act.Integrated environmental assessment and management · 2025Article
- Toxicokinetic-Toxicodynamic Model to Assess Thermal Stress.Environmental science & technology · 2023Article
- Mixture Toxicity of Three Unconventional Gas Fracking Chemicals, Barium, O-Cresol, and Sodium Chloride, to the Freshwater Shrimp Paratya australiensis.Environmental toxicology and chemistry · 2023Article
- Article
- BeeGUTS-A Toxicokinetic-Toxicodynamic Model for the Interpretation and Integration of Acute and Chronic Honey Bee Tests.Environmental toxicology and chemistry · 2022Article
- In Silico Methods for Environmental Risk Assessment: Principles, Tiered Approaches, Applications, and Future Perspectives.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current methods to assess the impact of chemical mixtures on organisms ignore the temporal dimension. The General Unified Threshold model for Survival (GUTS) provides a framework for deriving toxicokinetic-toxicodynamic (TKTD) models, which account for effects of toxicant exposure on survival in time. Starting from the classic assumptions of independent action and concentration addition, we derive equations for the GUTS reduced (GUTS-RED) model corresponding to these mixture toxicity concepts and go on to demonstrate their application. Using experimental binary mixture studies with
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