Evidence map›Paper›PMID 33499537›Full record

ArticleMilitary medicine2021

Approaches for Monitoring Warfighter Blast-related Exposures in Training to Develop Effective Safety Standards.

Steven Kornguth, Henry G Rylander, Spencer Smith, Julia Campbell, Steve Steffensen, David Arnold, Alex Athey, J Neal Rutledge

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Military medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Steven KornguthDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
Henry G RylanderDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Spencer SmithDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
Julia CampbellDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
Steve SteffensenDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
David ArnoldDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
Alex AtheyDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
J Neal RutledgeDepartment of Neurology, The University of Texas Dell Medical School, Austin, TX, 78712, USA.
The University of Texas at Austin · US

Funding

Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
Investigating the Relationship between Objective Measures of Binaural Hearing and Speech-in-Noise Performance in Middle-Aged ListenersK01DC017192 · NIDCD · UNIVERSITY OF TEXAS AT AUSTIN · PI SMITH, SPENCER · 2018 to 2020
$411k
NIBIB NIH HHS T32 EB007507NIDCD NIH HHS K01 DC017192
6 · The paper itself

Abstract

introductionTraumatic brain injuries are of concern to the sports and military communities because of the age of the participants and costly burden to society. To markedly reduce the impact of traumatic brain injury and its sequela (TBI-S), it is necessary to determine the initial vulnerability of individuals as well as identify new technologies that indicate early signs of TBI-S. MATERIALS AND

methodsCurrently, diverse methods have been used by the authors and others in laboratory settings to reveal early signs of persistent TBI-S including simulation modeling of the effect of rapid deceleration on the deviatoric strain (shear force) imposed on specific brain regions, auditory evoked potential (AEP) measurements to determine injury to the auditory cortex optokinetic nystagmus (OKN) measures sensitive to vestibular trauma, and optical coherence tomography (OCT) measures that reveal changes in central visual function obtained noninvasively by examination of the retina.

resultsSimulation studies provided technical information on maximal deviatoric strain at the base of the sulci and interface of gray and white matter consistent with results from neuropathology and from magnetic resonance imaging. The AEP and OKN reveal measurable injury to similar regions below the Sylvian fissure including auditory cortex and midbrain, and the OCT reveals changes to the retina consistent with forceful deceleration effects.

conclusionsThe studies and results are consistent with prior work demonstrating that noninvasive tests may be sensitive to the presence of TBI-S, potentially in the training field as advances in the portability of test instruments are underway. When combined with baseline data gathered from individuals in quantitative form, key variances can emerge. Therefore, it is hypothesized that AEP, OKN, and OCT, taken together, may yield faster objective and quantitative neurophysiological measures serving as a "signature" of neural injury and more indicative of potentially persistent TBI-S-recommending larger scale longitudinal studies.

Indexed as

Brain ConcussionBrain Injuries, TraumaticMilitary PersonnelAnimalsHumansMiceReference StandardsWhite Matter

Identifiers

PMID33499537
PMCPMC7980484
OpenAlexW3123980565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.