Evidence map›Paper›PMID 33499282›Full record

ArticleInternational journal of molecular sciences2021

In Silico Inference of Synthetic Cytotoxic Interactions from Paclitaxel Responses.

Jeong Hoon Lee, Kye Hwa Lee, Ju Han Kim

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 100% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Jeong Hoon LeeSeoul National University Biomedical Informatics (SNUBI), Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul 110799, Korea.ORCID 0000-0002-1789-8270
Kye Hwa LeeAsan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Ju Han KimSeoul National University Biomedical Informatics (SNUBI), Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul 110799, Korea.
Seoul National University · KRUlsan College · KR

Funding

National Research Foundation of Korea(NRF) funded by the Ministry of Education NRF-2018R1D1A1A02086109
6 · The paper itself

Abstract

To exploit negatively interacting pairs of cancer somatic mutations in chemotherapy responses or synthetic cytotoxicity (SC), we systematically determined mutational pairs that had significantly lower paclitaxel half maximal inhibitory concentration (IC

Indexed as

MutationAntineoplastic AgentsCarcinomaCell Line, TumorComputer SimulationEndometrial NeoplasmsFemaleGene Regulatory NetworksGenes, Tumor SuppressorGenome, HumanHumansInhibitory Concentration 50Kaplan-Meier EstimatePaclitaxelPrognosisProportional Hazards ModelsAntineoplastic AgentsPaclitaxelTP53 protein, humanTumor Suppressor Protein p53chemotherapy responseconditional synthetic lethalitypaclitaxelsynthetic cytotoxicityurogenital cancer

Identifiers

PMID33499282
PMCPMC7865701
OpenAlexW3123240209

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.