UV-Induced Reduction of ACVR1C Decreases SREBP1 and ACC Expression by the Suppression of SMAD2 Phosphorylation in Normal Human Epidermal Keratinocytes.

Yu-Dan Tian, Min Hwa Chung, Qing-Ling Quan, Dong Hun Lee, Eun Ju Kim, Jin Ho Chung

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 31% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Using single-sample networks to identify the contrasting patterns of gene interactions and reveal the radiation dose-dependent effects in multiple tissues of spaceflight mice.NPJ microgravity · 2024
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yu-Dan TianDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

Min Hwa ChungInstitute of Human-Environment Interface Biology, Medical Research Center, Seoul National University, Seoul 03080, Korea.

Qing-Ling QuanDepartment of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea.

Dong Hun LeeDepartment of Dermatology, Seoul National University College of Medicine, Seoul 03080, Korea.ORCID 0000-0002-2925-3074

Eun Ju KimDepartment of Dermatology, Seoul National University Hospital, Seoul 03080, Korea.

Jin Ho ChungDepartment of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.

Seoul National University · KRSeoul National University Hospital · KR

Funding

Ministry of Health & Welfare, Republic of Korea HI14C1277

6 · The paper itself

Abstract

Activin A receptor type 1C (ACVR1C), a type I transforming growth factor-β (TGF-β) receptor, has been implicated in sensitive skin and psoriasis and is involved in the regulation of metabolic homeostasis as well as cell proliferation and differentiation. In this study, we identified a novel role of ACVR1C in the ultraviolet (UV)-irradiation-induced reduction of epidermal lipogenesis in human skin. UV irradiation decreased ACVR1C expression and epidermal triglyceride (TG) synthesis in human skin in vivo and in primary normal human epidermal keratinocytes (NHEK) in vitro. Lipogenic genes, including genes encoding acetyl-CoA carboxylase (ACC) and sterol regulatory element binding protein-1 (SREBP1), were significantly downregulated in UV-irradiated NHEK. ACVR1C knockdown by shRNA resulted in greater decreases in SREBP1 and ACC in response to UV irradiation. Conversely, the overexpression of ACVR1C attenuated the UV-induced decreases in SREBP1 and ACC. Further mechanistic study revealed that SMAD2 phosphorylation mediated the ACVR1C-induced lipogenic gene modulation. Taken together, a decrease in ACVR1C may cause UV-induced reductions in SREBP1 and ACC as well as epidermal TG synthesis via the suppression of SMAD2 phosphorylation. ACVR1C may be a target for preventing or treating UV-induced disruptions in lipid metabolism and associated skin disorders.

Indexed as

Acetyl-CoA CarboxylaseActivin Receptors, Type IAdultCell DifferentiationCell ProliferationEpidermisHealthy VolunteersHumansKeratinocytesLipid MetabolismLipogenesisPhosphorylationRNA InterferenceSkinSmad2 ProteinSterol Regulatory Element Binding Protein 1ACACA protein, humanAcetyl-CoA CarboxylaseActivin Receptors, Type IACVR1C protein, humanSmad2 ProteinSMAD2 protein, humanSREBF1 protein, humanSterol Regulatory Element Binding Protein 1Triglyceridesacetyl CoA carboxylaseactivin A receptor type 1Cepidermal lipogenesisSMAD2 phosphorylationsterol regulatory element-binding protein-1ultraviolet

Identifiers

PMID33499275

DOI10.3390/ijms22031101

PMCPMC7865598

OpenAlexW3124793963

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.