ArticleInternational journal of molecular sciences2021
Bioactive Betulin and PEG Based Polyanhydrides for Use in Drug Delivery Systems.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Drug delivery system of curcumin to the lungs based on poly(3-alloxyloxy-1,2-propylene succinate)-sebacic acid copolymers.Journal of pharmaceutical analysis · 2026Article
- Drug Delivery Systems of Betulin and Its Derivatives: An Overview.Biomedicines · 2024Review
- New Biodegradable Copolymers Based on Betulin and Hydroxycarboxylic Acid Derivatives.Materials (Basel, Switzerland) · 2024Article
- Polyanhydride Microcapsules Exhibiting a Sharp pH Transition at Physiological Conditions for Instantaneous Triggered Release.Langmuir : the ACS journal of surfaces and colloids · 2023Article
- Polyanhydride Chemistry.Biomacromolecules · 2022Review
- Highly Branched Betulin Based Polyanhydrides for Self-Assembled Micellar Nanoparticles Formulation.International journal of molecular sciences · 2022Article
- Biodegradable and Bioactive Carriers Based on Poly(betulin disuccinate-Pharmaceutics · 2022Article
- Determination of Mechanical and Tribological Properties of Silicone-Based Composites Filled with Manganese Waste.Materials (Basel, Switzerland) · 2021Article
- Enhancement of the Antioxidant and Skin Permeation Properties of Betulin and Its Derivatives.Molecules (Basel, Switzerland) · 2021Article
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Authors and funding
5 authors.
Funding
Abstract
In the course of this study, a series of novel, biodegradable polyanhydrides based on betulin disuccinate and dicarboxylic derivatives of poly(ethylene glycol) were prepared by two-step polycondensation. These copolymers can be used as carriers in drug delivery systems, in the form of microspheres. Betulin and its derivatives exhibit a broad spectrum of biological activity, including cytotoxic activity, which makes them promising substances for use as therapeutic agents. Microspheres that were prepared from betulin based polyanhydrides show promising properties for use in application in drug delivery systems, including inhalation systems. The obtained copolymers release the active substance-betulin disuccinate-as a result of hydrolysis under physiological conditions. The use of a poly(ethylene glycol) derivative as a co-monomer increases the solubility and bioavailability of the obtained compounds. Microspheres with diameters in the range of 0.5-25 µm were prepared by emulsion solvent evaporation method and their physicochemical and aerodynamic properties were analyzed. The morphological characteristics of the microspheres depended on the presence of poly(ethylene glycol) (PEG) segment within the structure of polyanhydrides. The porosity of the particles depended on the amount and molecular weight of the PEG used and also on the speed of homogenization. The most porous particles were obtained from polyanhydrides containing 20% wt. of PEG 600 by using a homogenization speed of 18,000 rpm.
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