Evidence map›Paper›PMID 33499199›Full record

ArticleInternational journal of molecular sciences2021

Retinoid Regulation of Ocular Surface Innate Inflammation.

Jehan Alam, Zhiyuan Yu, Cintia S de Paiva, Stephen C Pflugfelder

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Keratoconus.Nature reviews. Disease primers · 2024
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tear proteomics in dry eye disease.Indian journal of ophthalmology · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jehan AlamDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Zhiyuan YuDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Cintia S de PaivaDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9057-5494
Stephen C PflugfelderDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-9341-3482
Baylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
PATHOGENESIS OF CONJUNCTIVAL SQUAMOUS METAPLASIAR01EY011915 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PFLUGFELDER, STEPHEN C · 1997 to 2023
$8.0M
Core Grant for Vision ResearchP30EY020799 · NEI · UT SOUTHWESTERN MEDICAL CENTER · PI NIEDERKORN, JERRY · 2010 to 2016
$4.1M
Cancer Prevention and Research Institute of Texas RP180672Hamill Foundation OphthalmologyNCI NIH HHS P30 CA125123NEI NIH HHS EY002520NEI NIH HHS EY020799NEI NIH HHS EY11915NEI NIH HHS P30 EY002520NEI NIH HHS R01 EY011915NIH HHS CA125123Research to Prevent Blindness URSid W. Richardson Foundation Ophthalmology
6 · The paper itself

Abstract

Corneal and conjunctival inflammation and dry eye develop in systemic vitamin A deficiency (VAD). The objective of this study was to investigate the lacrimal ocular surface retinoid axis, particularly immunomodulatory effects of retinoic acid (RA) and change in conjunctival myeloid cell number and phenotype in VAD. We discovered that ocular surface epithelial and myeloid cells express retinoid receptors. Both all

Indexed as

AnimalsChemokine CCL5ConjunctivaCorneaDry Eye SyndromesEyeFemaleGoblet CellsHomeostasisImmunity, InnateInflammationInterleukin-12 Subunit p35Interleukin-1betaLacrimal ApparatusMiceMice, Inbred C57BLChemokine CCL5Il12a protein, mouseIL1B protein, mouseInterleukin-12 Subunit p35Interleukin-1betaReceptors, Retinoic AcidRetinoidsTretinoinVitamin Aconjunctivacorneadry eyeinflammationNFκBretinoic acidretinol

Identifiers

PMID33499199
PMCPMC7866051
OpenAlexW3122346759

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.