Evidence map›Paper›PMID 33499186›Full record

ReviewInternational journal of molecular sciences2021

Autophagy in HCV Replication and Protein Trafficking.

Ja Yeon Kim Chu, Jing-Hsiung James Ou

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. Roles of the Keap1/Nrf2 pathway and mitophagy in liver diseases.Journal of Zhejiang University. Science. B · 2025
    Review
  4. Review
  5. Mechanism and regulation of mitophagy in liver diseases: a review.Frontiers in cell and developmental biology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. [Palmitic acid suppresses autophagy in neonatal rat cardiomyocytesNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  11. Hepatocytes: A key role in liver inflammation.Frontiers in immunology · 2022
    Review
  12. Article
  13. Article
  14. Regulators of liver cancer stem cells.World journal of stem cells · 2021
    Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ja Yeon Kim ChuDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Jing-Hsiung James OuDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-8274-5705
University of Southern California · US

Funding

NIH HHS DK094652
6 · The paper itself

Abstract

Autophagy is a catabolic process that is important for maintaining cellular homeostasis. It is also known to possess other functions including protein trafficking and anti-microbial activities. Hepatitis C virus (HCV) is known to co-opt cellular autophagy pathway to promote its own replication. HCV regulates autophagy through multiple mechanisms to control intracellular protein and membrane trafficking to enhance its replication and suppress host innate immune response. In this review, we discuss the current knowledge on the interplay between HCV and autophagy and the crosstalk between HCV-induced autophagy and host innate immune responses.

Indexed as

Protein TransportVirus ReplicationAutophagyCell MembraneHepacivirusHepatitis CHepatocytesHomeostasisHumansImmunity, InnateMembrane MicrodomainsMitochondriaMitophagyRNA, ViralSignal TransductionRNA, Viralautophagosome biogenesisautophagyHCV RNA replicationhepatitis C virusinnate immunitymitophagyprotein trafficking

Identifiers

PMID33499186
PMCPMC7865906
OpenAlexW3122478509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.