Evidence map›Paper›PMID 33499165›Full record

ArticleCancers2021

Lack of Electron Acceptors Contributes to Redox Stress and Growth Arrest in Asparagine-Starved Sarcoma Cells.

Christoph Bauer, Meret Quante, Willemijn B Breunis, Carla Regina, Michaela Schneider, Geoffroy Andrieux, Oliver Gorka, Olaf Groß, Melanie Boerries, Bernd Kammerer and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Reductive stress in cancer immunology and targeted therapy.Acta biochimica et biophysica Sinica · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Christoph BauerDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany.ORCID 0000-0003-1409-2252
Meret QuanteDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany.
Willemijn B BreunisDepartment of Oncology and Children's Research Center, University Children's Hospital, Steinwiessstrasse 75, 8032 Zürich, Switzerland.
Carla ReginaDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany.
Michaela SchneiderDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany.
Geoffroy AndrieuxInstitute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-5389-9481
Oliver GorkaInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany.ORCID 0000-0002-8245-3008
Olaf GroßInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany.
Melanie BoerriesInstitute of Medical Bioinformatics and Systems Medicine, Faculty of Medicine, Medical Center-University of Freiburg, University of Freiburg, 79104 Freiburg, Germany.
Bernd KammererCenter for Biological Systems Analysis (ZBSA), University of Freiburg, Habsburgerstrasse 49, 79104 Freiburg, Germany.
Simone HettmerDivision of Pediatric Hematology and Oncology, Department of Pediatric and Adolescent Medicine, University Medical Center Freiburg, University of Freiburg, Mathildenstrasse 1, 79106 Freiburg, Germany.ORCID 0000-0003-1709-4448
University of Freiburg · DEUniversity Children's Hospital Zurich · CH

Funding

Berta Ottenstein Programm Freiburg n/aBundesministerium für Bildung und Forschung FKZ 01ZX1708FDeutsche Forschungsgemeinschaft SFB1160Z2Förderverein für krebskranke Kinder Freiburg n/aSt. Baldrick's Foundation n/a
6 · The paper itself

Abstract

Amino acids are integral components of cancer metabolism. The non-essential amino acid asparagine supports the growth and survival of various cancer cell types. Here, different mass spectrometry approaches were employed to identify lower aspartate levels, higher aspartate/glutamine ratios and lower tricarboxylic acid (TCA) cycle metabolite levels in asparagine-deprived sarcoma cells. Reduced nicotinamide adenine dinucleotide (NAD

Indexed as

asparagine starvationmetabolomicsreductive stresssarcoma

Identifiers

PMID33499165
PMCPMC7865502
OpenAlexW3122461002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.