Evidence map›Paper›PMID 33499145›Full record

ArticleInternational journal of molecular sciences2021

The Role of Panx3 in Age-Associated and Injury-Induced Intervertebral Disc Degeneration.

Meaghan Serjeant, Paxton M Moon, Diana Quinonez, Silvia Penuela, Frank Beier, Cheryle A Séguin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Ultrasound guidance for intervertebral disc location and paravertebral tissue swelling quantification in a mouse model of intervertebral disc herniation.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Pannexin 3 channels in health and disease.Purinergic signalling · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Meaghan SerjeantDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Paxton M MoonDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Diana QuinonezDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Silvia PenuelaBone and Joint Institute, The University of Western Ontario, London, ON N6A 5C1, Canada.ORCID 0000-0003-4829-5517
Frank BeierDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Cheryle A SéguinDepartment of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6A 5C1, Canada.
Western University · CA

Funding

CIHR 332438
6 · The paper itself

Abstract

Pannexin 3 (Panx3) is a mechanosensitive, channel-forming glycoprotein implicated in the progression of post-traumatic osteoarthritis. Despite evidence for

Indexed as

AgingAnimalsAnnulus FibrosusConnexinsDisease Models, AnimalGene Expression RegulationGenotypeIntervertebral DiscIntervertebral Disc DegenerationMiceMice, Inbred C57BLMice, KnockoutNucleus PulposusProteoglycansPuncturesStress, MechanicalConnexinspannexin 3 protein, mouseProteoglycansintervertebral disc degenerationmechanical stressneedle puncture injurypannexin 3transgenic mice

Identifiers

PMID33499145
PMCPMC7865929
OpenAlexW3124081322

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.