Evidence map›Paper›PMID 33499115›Full record

ArticleBiomolecules2021

DNA Methylation Profiles of

Mariella Cuomo, Luca Borrelli, Rosa Della Monica, Lorena Coretti, Giulia De Riso, Luna D'Angelo Lancellotti di Durazzo, Alessandro Fioretti, Francesca Lembo, Timothy G Dinan, John F Cryan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
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  4. Observational
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  6. Article
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  9. Application of zebrafish in the study of the gut microbiome.Animal models and experimental medicine · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Mariella CuomoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Luca BorrelliDepartment of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Via Delpino 1, 80137 Naples, Italy.ORCID 0000-0001-5650-7458
Rosa Della MonicaCEINGE Biotecnologie Avanzate, via Gaetano Salvatore 482, 80145 Naples, Italy.
Lorena CorettiTask Force on Microbiota Studies University of Naples "Federico II" of Naples, 80131 Naples, Italy.
Giulia De RisoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.ORCID 0000-0001-6096-132X
Luna D'Angelo Lancellotti di DurazzoDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Alessandro FiorettiDepartment of Veterinary Medicine and Animal Productions, University of Naples "Federico II", Via Delpino 1, 80137 Naples, Italy.
Francesca LemboTask Force on Microbiota Studies University of Naples "Federico II" of Naples, 80131 Naples, Italy.
Timothy G DinanDepartment of Psychiatry and Neurobehavioural Science, APC Microbiome Institute, University College Cork, T12 YT20 Cork, Ireland.ORCID 0000-0002-2316-7220
John F CryanDepartment of Psychiatry and Neurobehavioural Science, APC Microbiome Institute, University College Cork, T12 YT20 Cork, Ireland.
Sergio CocozzaDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
Lorenzo ChiariottiDepartment of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy.
University of Naples Federico II · ITCeinge Biotecnologie Avanzate (Italy) · ITFederico II University Hospital · ITUniversity College Cork · IE

Funding

REGIONE CAMPANIA POR Campania FESR 2014-2020 "SATIN" grant
6 · The paper itself

Abstract

The bidirectional microbiota-gut-brain axis has raised increasing interest over the past years in the context of health and disease, but there is a lack of information on molecular mechanisms underlying this connection. We hypothesized that change in microbiota composition may affect brain epigenetics leading to long-lasting effects on specific brain gene regulation. To test this hypothesis, we used

Indexed as

DNA MethylationAllelesAnimalsBehavior, AnimalBrainBrain-Derived Neurotrophic FactorComputational BiologyCpG IslandsEpigenesis, GeneticFemaleGastrointestinal MicrobiomeGene Expression ProfilingGene Expression RegulationGene LibraryLacticaseibacillus rhamnosusMaleBrain-Derived Neurotrophic FactorTryptophan Hydroxylasecell-to-cell heterogeneityDNA methylationepiallelesmethylation profilesmicrobiota–gut–brain axisZebrafish

Identifiers

PMID33499115
PMCPMC7911505
OpenAlexW3121157705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.