Evidence map›Paper›PMID 33499035›Full record

ArticleJournal of clinical medicine2021

Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin Receptor Blockers on Acute Kidney Injury in Emergency Medical Admissions.

Athanasios Feidakis, Maria-Rosa Panagiotou, Emmanouil Tsoukakis, Dimitra Bacharaki, Paraskevi Gounari, Petros Nikolopoulos, Katerina P Marathias, Sophia Lionaki, Demetrios Vlahakos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

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  10. Nephrotoxicity in cancer treatment: An update.Advances in cancer research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Athanasios Feidakis2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Maria-Rosa Panagiotou2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Emmanouil Tsoukakis2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Dimitra Bacharaki2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Paraskevi Gounari2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Petros Nikolopoulos2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
Katerina P MarathiasIntensive Care Unit, Onassis Cardiac Surgery Center, 17674 Athens, Greece.
Sophia Lionaki2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.ORCID 0000-0003-1643-8923
Demetrios Vlahakos2nd Department of Internal Medicine, National and Kapodistrian University of Athens Medical School, Attikon University Hospital, 1 Rimini Street, Haidari, 11527 Athens, Greece.
National and Kapodistrian University of Athens · GROnassis Cardiac Surgery Center · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) has been observed in up to 20% of adult hospital admissions. Sepsis, diarrhea and heart failure, all causing reduced effective volume, are considered risk factors for AKI, especially among patients treated with medications that block the Renin-Angiotensin System (RAS), such as angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB). We aimed to determine the incidence of acute kidney injury (AKI) in emergency medical admissions in relation to the use and dosage of ACEi/ARB.

methodsA single-center observational study conducted in 577 consecutive medical admissions via the Emergency Room (ER) at a University General Hospital in Athens, Greece, between June and July 2018. Patients with incomplete medical records, discharged within 24 h, maintained on chronic renal replacement therapy, admitted to the Cardiology Department or the ICU were excluded. Thus, a total of 309 patients were finally included in this analysis.

resultsWe compared 86 (28%) patients who presented in the ER with AKI (AKIGroup) with 223 (72%) patients without AKI (non-AKI Group) at the time of admission. Patients in the AKI Group were more frequently male (58% vs. 46%,

conclusionThe risk of AKI in emergency medical admissions is higher among users of ACEIs/ARB at target or above target dosages. Physicians should adjust RAS blockade according to estimated Glomerular Filtration Rate (eGFR) and advise their patients to withhold ACEi/ARB in cases of acute illness.

Indexed as

acute kidney injuryangiotensin-converting enzyme inhibitorsangiotensin receptor blockersemergency medical admission

Identifiers

PMID33499035
PMCPMC7865425
OpenAlexW3124860671

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.