ReviewMicromachines2021
Electrophysiology Read-Out Tools for Brain-on-Chip Biotechnology.
Review in Micromachines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Chemically Selective Nanoelectrode Arrays for Real-Time, Parallel Neurotransmitter and Electrical Recording.Small science · 2026Article
- Engineering Brain Injury In Vitro: Human iPSC-Based Organoids in Microfluidic Systems.Applied sciences (Basel, Switzerland) · 2026Article
- Advancing neuroengineering with Neuromorphic Twins.Nature communications · 2026Review
- Constructive Neuroengineering of Crossing Multi-Neurite Wiring Using Modifiable Agarose Gel Platforms.Gels (Basel, Switzerland) · 2025Article
- Seamless integration of CMOS microsensors into open microfluidic systems.Lab on a chip · 2025Article
- Ex vivo study of neuroinvasive and neurotropic viruses: what is current and what is next.FEMS microbiology reviews · 2025Review
- Article
- Mind In Vitro Platforms: Versatile, Scalable, Robust, and Open Solutions to Interfacing with Living Neurons.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Epileptiform activity in brain organoids derived from patient with Glucose Transporter 1 Deficiency Syndrome.Frontiers in neuroscience · 2024Article
- Versatile micro-electrode array to monitor human iPSC derived 3D neural tissues at air-liquid interface.Frontiers in cellular neuroscience · 2024Article
- Evaluation of prophylactic efficacy of sodium thiosulfate in combating I/R injury in rat brain: exploring its efficiency further in vascular calcified brain slice model.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Toward the Next Generation of Neural Iontronic Interfaces.Advanced healthcare materials · 2023Article
- Microfluidics for Neuronal Cell and Circuit Engineering.Chemical reviews · 2022Review
- Advances in construction and modeling of functional neural circuits in vitro.Neurochemical research · 2022Article
- Article
- Lightsheet optical tweezer (LOT) for optical manipulation of microscopic particles and live cells.Scientific reports · 2022Article
- A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry.Micromachines · 2021Article
- The Future of Neurotoxicology: A Neuroelectrophysiological Viewpoint.Frontiers in toxicology · 2021Article
- Editorial for the Special Issue on Microfluidic Brain-on-a-Chip.Micromachines · 2021Article
- Brain-on-a-Chip: Characterizing the next generation of advancedAPL bioengineering · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Brain-on-Chip (BoC) biotechnology is emerging as a promising tool for biomedical and pharmaceutical research applied to the neurosciences. At the convergence between lab-on-chip and cell biology, BoC couples in vitro three-dimensional brain-like systems to an engineered microfluidics platform designed to provide an in vivo-like extrinsic microenvironment with the aim of replicating tissue- or organ-level physiological functions. BoC therefore offers the advantage of an in vitro reproduction of brain structures that is more faithful to the native correlate than what is obtained with conventional cell culture techniques. As brain function ultimately results in the generation of electrical signals, electrophysiology techniques are paramount for studying brain activity in health and disease. However, as BoC is still in its infancy, the availability of combined BoC-electrophysiology platforms is still limited. Here, we summarize the available biological substrates for BoC, starting with a historical perspective. We then describe the available tools enabling BoC electrophysiology studies, detailing their fabrication process and technical features, along with their advantages and limitations. We discuss the current and future applications of BoC electrophysiology, also expanding to complementary approaches. We conclude with an evaluation of the potential translational applications and prospective technology developments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.