ArticleInternational journal of environmental research and public health2021
Treatment of Stage 2 Medication-Induced Osteonecrosis of the Jaw: A Case Series.
Article in International journal of environmental research and public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- Comparison between different intermaxillary fixation systems in the surgical and orthopedic treatment of non-condylar mandibular fractures. Systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Efficacy of leukocyte- and platelet-rich fibrin in the treatment and prevention of medication-related osteonecrosis of the jaw: a prospective study.Medicina oral, patologia oral y cirugia bucal · 2025Article
- A Systematic Review on Prior/Postoperative Antibiotics Therapy Efficiency in Reducing Surgical Complications After Third Molar Extraction Surgery.Journal of maxillofacial and oral surgery · 2025Review
- Treatment of Medication-Related Osteonecrosis of the Jaw Without and With the Use of Advanced Platelet-Rich Fibrin: A Retrospective Clinical Study.Journal of functional biomaterials · 2025Article
- Autologous platelet concentrates as adjuvant in the surgical management of medication-related osteonecrosis of the jaw.Periodontology 2000 · 2025Review
- Treatment of Medication-Related Osteonecrosis of the Jaws without Segmental Resections: A Case Series.The American journal of case reports · 2024Article
- Clinical and Histopathological Aspects of MRONJ in Cancer Patients.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medication-induced jaw osteonecrosis (MRONJ) is a rare and serious disease with a negative impact on patients' quality of life, whose exact cause remains unclear and which may have a multifactorial origin. Although there are different therapeutic protocols, there is still no consensus. This case series evaluated three patients diagnosed with staged 2 MRONJ treated at the University of Murcia dental clinic according to the protocols described by the Spanish Society of Oral and Maxillofacial Surgery and the American Association of Oral and Maxillofacial Surgeons. Within 12 months of the application of therapeutic protocols, the lesions were completely healed in all cases. Radiography showed slow but progressive healing with normal bone structure. Conservative treatment with antibiotics, chlorhexidine rinses and minimally invasive surgical intervention with necrotic bone resection is effective in treating stage 2 of MRONJ. In cases of refractory osteonecrosis, the application of platelet and leukocyte-rich fibrin (PRF-L) in the surgical approach improves the outcome in soft tissue healing and bone regeneration but further research is needed to confirm its effectiveness.
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